2021年6月19日 · Measurable residual disease (MRD) status of patients undergoing treatment for acute myeloid leukaemia (AML) is important for prognosis and guides treatment. Multicolour flow cytometry (MCF) is a sensitive MRD method. The current approach relies on identification of blasts expressing leukaemia-associ …

反洗钱法（AML，Anti-Money Laundering）与反恐融资法（CFT，Combating the Financing of Terrorism）是全球金融监管的重要组成部分。 它们旨在通过一系列立法、监管和合规措施，防止洗钱和恐怖主义融资活动的发生…

2024年1月17日 · We firstly identified the prognostic value of MFC MRD detected at three critical timepoints before allo-HSCT in a disease-specific population of adults with adverse-risk AML, and our results ...

2024年12月13日 · 对于急性髓系白血病（AML），前50年的研究主要集中在阿糖胞苷联合蒽环类药物，并在策略方面取得了一定进展，包括异基因造血干细胞移植、大剂量阿糖胞苷、支持治疗措施和急性早幼粒细胞白血病患者的靶向治疗。 2017年是AML研究的转折点，此后已有12种不同机制的药物在美国获批治疗AML。 此外，口服decitabine-cedazuridine已获批作为骨髓增生异常综合征肠外去甲基化药物的生物等效替代药物，可用于AML治疗；Menin抑制剂、CD123抗体-药 …

Measurable residual disease (MRD) using flow cytometry is a valuable tool for the prediction of relapse in AML using conventional therapies and ven/aza; however, the prognostic value for broad-scale molecular MRD after ven/aza treatment is less clear.

2023年11月2日 · Results: We found a concordance of 76% between MCF cases and RUNX1/RUNX1T1 qPCR, and a concordance of 83% between MCF cases and CBFB/MYH11 qPCR (Tables 1a and 1b). In relapsed cases we observed a dynamic and continuous increase of abnormal MCF events, that was not found in cases without clinical relapse although with positive qPCR (Table 2).

2024年8月21日 · Multiparameter flow cytometry (MFC)-based MRD testing is increasingly utilized in AML, but methodologies and assay characteristics vary substantially [1,2,3].

Effective anti-money laundering and combating the financing of terrorism (AML/CFT) policies and measures are key to the integrity and stability of the international financial system and member countries’ economies.

2020年11月5日 · Acute myeloid leukemia (AML) was defined by an increase of immature myeloid cells, or blasts that exceed ≥20% in bone marrow or peripheral blood. Many lines of evidence suggest that the development of AML is shaped by clonal evolution through multiple rounds of positive selection driven by newly acquired mutations, ultimately leading to an ...

2021年12月30日 · Supplemental Table 2 summarizes recent clinical studies incorporating multiparameter flow cytometry (MFC)-MRD assessment in AML, including for randomized treatment comparisons 4,5 and MRD-directed therapy. 6,7 Herein, we update current best practices (Table 1).