A stem cell transplant (SCT), also known as a bone marrow transplant (BMT), lets doctors give higher doses of treatment to try to cure acute myeloid leukemia (AML). This treatment is intense, and not everyone with AML is a good candidate for it.

The stem cells of acute myeloid leukemia (AML) are the malignancy initiating cells whose survival ultimately drives growth of these lethal diseases. Here we review leukemia stem cell (LSC) biology, particularly as it relates to the very heterogeneous nature of AML and to …

Allogeneic stem cell transplant (allo-SCT) represents a pivotally important treatment strategy in fit adults with AML because of its augmented anti-leukemic activity consequent upon dose intensification and the genesis of a potent graft-versus-leukemia effect.

2024年8月21日 · In addition, single cell RNA-seq analysis uncovered signatures of stem, progenitor and mature AML cells that enabled the development of a hierarchy classification system that predicts drug ...

2024年11月5日 · Acute myeloid leukemia (AML) is a highly aggressive and deadly blood cancer with less than 30% five-year survival. AML develops when hematopoietic stem cells (HSC) or hematopoietic stem and progenitor cells (HSPC) acquire key mutations resulting in leukemic stem cell (LSC) transformation.

5 天之前 · Allogenic hematopoietic stem cell transplantation (allo-HSCT) emerged over sixty years ago as a groundbreaking and potentially curative treatment for patients with acute myeloid leukemia 1 who ...

You might have a stem cell or bone marrow transplant as part of your treatment for acute myeloid leukaemia (AML). Having a transplant means destroying as many leukaemia cells as possible and replacing these with healthy stem cells.

3 天之前 · Focused research in acute myeloid leukemia (AML) biology and treatment has led to the identification of new therapeutic targets and several new drug approvals over the last decade. ... More patients with AML are now able to undergo a consolidative allogeneic hematopoietic stem cell transplantation (HSCT), and the rates of nonrelapse mortality ...

2025年3月15日 · AML stem/progenitor cells express and depend on the activity of BRG1/BRM [5,6,7], which is essential for lineage specific gene expressions.

To prospectively and functionally identify the origin of MLL-AML stem cells, we reconstructed human AML cells using highly purified and functionally validated human hematopoietic cells isolated from umbilical cord blood (fig. S1A).