硫辛酸(α-Lipoic acid, ALA) 为一个硫化有机物的抗氧化化合物，硫辛酸通过CaKK信号通路激活AMPK，调控糖代谢；激活胰岛素受体β亚基（IR β），提高机体胰岛素敏感性；提高线粒体氧化呼吸强度，加速线粒体活动，增加机体对葡萄糖的摄取和利用，能透过活化SIRT1和 ...

AMP-activated protein kinase (AMPK) enhances glucose transporter GLUT4 regulation. AMPK also suppresses energy-consuming pathways such as cholesterol synthesis. Interestingly, recent in vitro and in vivo data suggest that excess membrane cholesterol impairs GLUT4 regulation.

2022年2月1日 · AMPK signaling can significantly enhance glucose uptake in muscle and other cells to reduce serum glucose levels via upregulating GLUT1 and GLUT4 as its transporters. Furthermore, AMPK signaling is beneficial in enhancing glucose metabolism in cells via inducing SIRT1 and promoting PGC-1α expression.

我们以前的研究表明，E.Phaseoloides中的三萜皂苷通过激活AMP激活的蛋白激酶（AMPK）在2型糖尿病大鼠中具有抗糖尿病作用。 有人提出从菜豆的种子仁中分离出主要的糖苷配子酸，它在抗糖尿病作用中起着重要的作用，但是其实际作用和相关机制仍是未知的。

Activation of AMP-activated protein kinase (AMPK) results in glucose transporter 4 (GLUT4) translocation from the cytosol to the cell membrane, and glucose uptake in the skeletal muscles. This increased activation of AMPK can be stimulated by a ...

ampk激活后，会刺激葡萄糖转运蛋白4型(glut4)易位至质膜，从而主动促进骨骼肌中葡萄糖的摄取增加，从而通过糖酵解产生atp 。 Treebak等认为GLUT4从骨骼肌向质膜的易位是通过TBC1D1的磷酸化介导的 [ 20 ] ，TBC1D1的磷酸化增加Rab家族G蛋白的活性并诱导GLUT4囊泡与质膜的 ...

机制研究表明，过表达失活型Rab5a突变体S34N抑制GLUT4的转位;激活细胞内的能量感受蛋白AMPK能够增加Rab5a活性并促进GLUT4的转位。 通过蛋白质谱筛选Rab5a的互作分子，证明了TBC1D17是Rab5a的GAP蛋白。

2021年4月20日 · Here we report Tmod3, an actin filament capping protein, as a novel AMPK substrate and an essential mediator of AMPK-dependent GLUT4 translocation and glucose uptake in myoblasts. Furthermore, Tmod3 plays a key role in AMPK-induced F-actin remodeling and GLUT4 insertion into the PM.

To determine whether the increase in glucose uptake following AMP-activated protein kinase (AMPK) activation in adipocytes is mediated by accelerated GLUT4 translocation into plasma membrane, we constructed a chimera between GLUT4 and enhanced green fluorescent protein (GLUT4-eGFP) and transferred i …

2008年4月1日 · RESEARCH DESIGN AND METHODS AND RESULTS—Here, we report that AMP-activated protein kinase (AMPK) regulates GLUT4 transcription through the histone deacetylase (HDAC)5 transcriptional repressor. Overexpression of HDAC5 represses GLUT4 reporter gene expression, and HDAC inhibition in human primary myotubes increases endogenous GLUT4 gene ...