AMP-activated protein kinase (AMPK) has been shown to activate p53 in response to metabolic stress. However, the underlying mechanisms remain unclear. Here we show that metabolic stresses induce AMPK-mediated phosphorylation of human MDMX on Ser342 ...

2005年4月29日 · AMPK-induced p53 activation promotes cellular survival in response to glucose deprivation, and cells that have undergone a p53-dependent metabolic arrest can rapidly reenter the cell cycle upon glucose restoration. However, persistent activation of AMPK leads to accelerated p53-dependent cellular senescence.

Our previous studies indicated that calcitonin gene-related peptide (CGRP) alleviates hyperoxia-induced lung injury and suggested the possible involvement of autophagy in this process. Herein, we aimed to further explore the potential involvement of tumor protein p53 …

2024年3月19日 · TP53 mediates the effect of CGRP on the regulation of AMPK/MTOR signaling in MEL-12 cells exposed to hyperoxia. a Quantitative RT-PCR determination of the mRNA expression levels of PRKAA1, CASP3, MTOR, TP53, BECN1, CGRP, and BCL2 in MLE-12 cells subjected to different indicated treatments. b Western …

2008年5月4日 · The regulation of AMPK β1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1–AKT–mTOR pathways.

2022年4月8日 · When AMP-activated protein kinase (AMPK) is upregulated by TP53, it promotes autophagy through the transcriptional activation of SESTRIN 1 and 2. Of note, AMPK can also upregulate TP53 via...

2018年10月10日 · In the present study, we report that GOF mutant p53 proteins inhibit SESN1 expression and consequently the amount of the SESN1/AMPK complex, resulting in the inhibition of AMPK signaling and of proliferator-activated receptor gamma coactivator-1 …

2005年4月29日 · AMPK-induced p53 activation promotes cellular survival in response to glucose deprivation, and cells that have undergone a p53-dependent metabolic arrest can rapidly reenter the cell cycle upon glucose restoration. However, persistent activation of AMPK leads to accelerated p53-dependent cellular senescence.

AMP-activated protein kinase (AMPK) has been shown to activate p53 in response to metabolic stress. However, the underlying mechanisms remain unclear. Here we show that metabolic stresses induce AMPK-mediated phosphorylation of human MDMX on Ser342 in vitro and in cells, leading to enhanced associat …

Knockdown of SLC45A4 inhibits both glucose utilization and ATP production in TP53 mutant PDA cells and activates the AMPK/ULK1 signaling pathway, resulting in the induction of autophagy.