2023年12月6日 · UGT2B15 was partially responsible for the AR-induced invasive phenotype in ESCC cells. Importantly, simultaneous blocking of AP-1 and AR resulted in stronger inhibition of cell invasiveness compared to inhibiting AP-1 or AR alone.

2009年9月16日 · In the present study, we demonstrate for the first time, constitutive activation of AP-1 in ESCCs and change in binding partners that form active AP-1complex in ESCCs. ESCC with HPV infections constituted a significant proportion (19%; 14/75) and interestingly all these cases harbored the most prevalent high-risk HPV type 16.

We found that the region -87/-32 containing consensus Sp1 (-75/-69) and AP-1 (-64/-58) binding sites is crucial for VIL2 promoter activity in esophageal carcinoma cells (EC109) derived from ESCC. AP-1 is comprised of c-Jun and c-Fos.

2014年5月5日 · Moreover, transcription factor AP1, a downstream effector of the Ras-MAPK pathway, is linked to the pathogenesis of ESCC. A common feature of the promoter regions of these genes is the presence of AP1 DNA binding sites, and regulated by TPA-induced c-Jun/AP1 mainly via a PKC/JNK pathway in esophageal cancer cell line KYSE450 [29].

2009年3月20日 · We found that the region -87/-32 containing consensus Sp1 (-75/-69) and AP-1 (-64/-58) binding sites is crucial for VIL2 promoter activity in esophageal carcinoma cells (EC109) derived from ESCC. AP-1 is comprised of c-Jun and c-Fos.

2023年12月6日 · Our findings reveal the molecular mechanisms of AR in esophageal cancer invasion and identify the AP1-directed AR transcriptional activation of UGT2B15 as a potential therapeutic target for esophageal cancer metastasis. Esophageal squamous cell carcinoma (ESCC) is an aggressive epithelial malignancy with poor prognosis.

Moreover, transcription factor AP1, a downstream effector of the Ras-MAPK pathway, is linked to the pathogenesis of ESCC. A common feature of the promoter regions of these genes is the presence of AP1 DNA binding sites, and regulated by TPA-induced c-Jun/AP1 mainly via a PKC/JNK pathway in esophageal cancer cell line KYSE450 [29].

2009年9月16日 · Results: A high DNA binding activity and elevated expression of AP-1 proteins were observed in esophageal cancer, which differed between HPV positive (19%) and HPV negative (81%) carcinomas. While JunB, c-Fos and Fra-1 were the major contributors to AP-1 binding activity in HPV negative cases, Fra-1 was completely absent in HPV16 positive cancers.

2022年10月20日 · Ap1, a cell-internalizing aptamer that can specifically bind to ESCC cell line. The internalization of Ap1 into ESCC cells in vitro was verified by using flow cytometry and confocal microscopy. Besides, Ap1 can bind to ESCC cells in tissue chips, indicating that Ap1 was feasible for detecting ESCC cells.

To elucidate the role of p12CDK2-AP1 expression in esophageal squamous cell carcinoma (ESCC), we immunohistochemically examined the expression of p12CDK2-AP1 protein in 120 resected ESCC specimens and determined its association with the clinicopathological characteristics and prognosis.