Apolipoprotein A-V is a protein that in humans is encoded by the APOA5 gene on chromosome 11. [5][6][7] It is significantly expressed in liver. [8] . The protein encoded by this gene is an apolipoprotein and an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease.

2024年12月24日 · APOA5 (Apolipoprotein A5) is a Protein Coding gene. Diseases associated with APOA5 include Hypertriglyceridemia 1 and Hyperlipoproteinemia, Type V. Among its related pathways are Plasma lipoprotein assembly, remodeling, and clearance and Familial hyperlipidemia type 1.

2025年2月8日 · Gene ID: 116519, updated on 8-Feb-2025. The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease.

已确定载脂蛋白A5（apoA5）在脂质代谢中起重要作用，特别是在甘油三酸酯（TG）和富含TG的脂蛋白（TRLs）代谢中。 大量证据表明apoA5与肥胖症和代谢综合征风险增加之间存在关联，但其机制尚待充分阐明。

Apolipoprotein (apo) A5 (also referred to as apoA-V) is an intriguing exchangeable apolipoprotein that was discovered in 2001 by reverse genetics [1, 2]. APOA5 localizes to the APOA1, APOC3, APOA4 gene cluster on chromosome 11q23.

This review addresses two major functions of apolipoprotein (apo) A5 including (1) its role in maintaining normal plasma levels of circulating triglyceride (TG) and (2) its role as a component of hepatic lipid droplets. ApoA5 is synthesized solely in …

2022年9月1日 · The discovery of apolipoprotein A5 (APOA5) in 2001 has raised a number of intriguing questions about its role in lipid transport and triglyceride (TG) homeostasis. Genome-wide association studies have consistently identified APOA5 as a regulator of plasma TG levels, which is further supported by studies in transgenic and knockout mouse models ...

该基因编码的蛋白质是一种载脂蛋白，在调节血浆甘油三酯水平方面发挥着重要作用，而血浆甘油三酯水平是冠状动脉疾病的主要危险因素。 它是高密度脂蛋白的组成部分，与大鼠蛋白高度相似，在肝损伤时上调。 该基因的突变与高甘油三酯血症和 5 型高脂蛋白血症有关。 该基因位于染色体 11q23 上载脂蛋白基因簇的近端。 已经鉴定出编码相同蛋白质的可变剪接转录物变体。 [RefSeq 提供，2009 年 10 月]

2025年2月8日 · It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23.

APOA5（Apolipoprotein A5）是一种编码蛋白质的基因，它在血脂代谢和心血管健康中发挥着至关重要的作用。 APOA5编码的蛋白质是高密度脂蛋白（HDL）的一个重要成分，它参与了脂质代谢的调控和胆固醇的运输。