Apolipoprotein C-II (Apo-CII, or Apoc-II), or apolipoprotein C2 is a protein that in humans is encoded by the APOC2 gene. The protein encoded by this gene is secreted in plasma, where it is a component of very low density lipoproteins and chylomicrons.

2024年12月24日 · APOC2 (Apolipoprotein C2) is a Protein Coding gene. Diseases associated with APOC2 include Apolipoprotein C-Ii Deficiency and Familial Apolipoprotein C-Ii Deficiency. Among its related pathways are Plasma lipoprotein assembly, remodeling, and clearance and Visual phototransduction.

1999年3月1日 · ApoC2 is an important activator of LPL and is required for efficient lipolysis of TG-rich lipoproteins in the circulation. The total absence of apoC2 or defects in its structure severely hamper LPL-mediated lipolysis of TG-rich lipoproteins, resulting in …

该基因编码属于载脂蛋白基因家族的脂质结合蛋白。 该蛋白质在血浆中分泌，是极低密度脂蛋白的组成部分。 这种蛋白质激活脂蛋白脂肪酶，水解甘油三酯，从而为细胞提供游离脂肪酸。 该基因的突变会导致 IB 型高脂蛋白血症，其特征是高甘油三酯血症、黄色瘤以及胰腺炎和早期动脉粥样硬化的风险增加。 该基因与其他相关载脂蛋白基因一起存在于 19 号染色体上的簇中。 该基因与邻近的上游载脂蛋白 C-IV (APOC4) 基因之间存在自然发生的通读转录。 [RefSeq 提供，2011 …

2024年9月18日 · Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19.

2025年2月8日 · Both common and rare DNA variants of APOC2 gene were found in 10% patients with severe hypertriglyceridemia; Hydrolysis activated by APOC2 was faster compared with the LPL-mediated lipolysis of emulsion triolein. The binding density of APOC2 was less for small emulsion surfaces than for large ones.

载脂蛋白 C2 (APOC2) 是脂蛋白脂肪酶的激活剂，参与甘油三酯、极低密度脂蛋白和高密度脂蛋白的水解以释放游离脂肪酸 (FA)。 1 FA 氧化已成为癌症生存和生长的重要能量来源。 2癌症中APOC2 基因组学和转录组学改变的模式仍未探索。 在这里，我们通过分析 176 项研究（补充方法）来描述癌症中 APOC2失调的特征。 在 34 种不同癌症的 46706 个样本中（表 S1），扩增、突变和深度缺失是主要鉴定的 APOC2 改变（图 S1A）。 大约 1%（25 1 名患者）在APOC2 中有 …

Our study provides a novel ApoC2-deleted mammalian model with severe hypertriglyceridemia that was fully characterized and highlights a potential therapeutic approach for the treatment of ApoC2 deficient patients.

2024年3月5日 · APOC2 apolipoprotein C2 Gene ID: 344, updated on 5-Mar-2024 Gene type: protein coding Also known as: APO-CII; APOC-II. See all available tests in GTR for this gene; Go to complete Gene record for APOC2; Go to Variation Viewer for APOC2 variants; Summary. This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family.

APOC2 promoted GC cell invasion, migration, and proliferation via CD36-mediated PI3K/AKT/mTOR signaling activation. Furthermore, APOC2-CD36 axis upregulated EMT markers of GC cells via increasing the phosphorylation of PI3K, AKT, and mTOR.