What is the APOL1 Gene? Apolipoprotein L1 (APOL1) is a gene located on chromosome 22, and has two coding variants, G1 and G2. APOL1 produces a protein that is a component of …

2022年2月25日 · Genetic coding variants in APOL1, which encodes apolipoprotein L1 (APOL1), were identified in 2010 and are relatively common among individuals of sub-Saharan African …

2024年2月8日 · Learn about APOL1-Mediated Kidney Disease (AMKD), its causes, symptoms, and treatments. Find information on genetic testing, complications, and management. AMKD …

2024年2月8日 · Two variant alleles of the gene apolipoprotein L1 (APOL1), known as risk variants (RVs), are a major contributor to kidney disease burden in those of African descent. The …

2024年4月20日 · APOL1 (OMIM 603743) encoding apolipoprotein L1 (apoL1) is an evolutionarily new gene found only in humans and some primates with key roles in innate immunity against …

2024年10月26日 · Apolipoprotein L1 gene (APOL1) variants are risk factors for chronic kidney disease (CKD) among Black Americans. Data are sparse on the genetic epidemiology of CKD …

2024年12月24日 · APOL1 (Apolipoprotein L1) is a Protein Coding gene. Diseases associated with APOL1 include Focal Segmental Glomerulosclerosis 4 and Glomerulonephritis. Among its …

2024年2月14日 · Homozygous Apolipoprotein L1 (APOL1) variants G1 and G2 cause APOL1-mediated kidney disease, purportedly acting as surface cation channels in podocytes.

APOL1 kidney disease is a unique case in the field of the genetics of common disease: 2 variants (termed G1 and G2) with high population frequency have been repeatedly associated with …

2022年2月28日 · Polymorphisms in the gene for apolipoprotein L1 (APOL1) contribute significant risk to several forms of nondiabetic kidney disease, including focal segmental …