Arp2/3 complex (Actin Related Protein 2/3 complex) is a seven-subunit protein complex that plays a major role in the regulation of the actin cytoskeleton. It is a major component of the actin cytoskeleton and is found in most actin cytoskeleton-containing eukaryotic cells. [2]

Arp2/3复合体（英语：Arp2/3 complex）是一个包含7个次单元的蛋白质，专门调控 肌动蛋白 （actin） 细胞骨架。 其中Arp2与Arp3属于肌动蛋白相关蛋白（Actin-Related Proteins），能对微丝进行核化（nucleation）。 整个复合体则能够与微丝结合，并且使促使新的微丝生成。 Arp2/3复合体呈椭圆形，长约15nm、宽约14nm，厚约7-10nm ，由七条保守的多肽链组成。 其中，ARP2与ARP3两个亚基，为肌动蛋白相关蛋白（actin related protein），另外5个亚基按照 …

2006年10月1日 · Class II NPFs bind to the ARP2/3 complex and actin filaments and stabilize ARP2/3-mediated branches. Branching by the ARP2/3 complex is crucial for generating actin networks that are ideally...

Arp2 and Arp3 are both subunits of a seven-member protein complex, called the ‘Arp2/3 complex’ that is an essential regulator of the actin cytoskeleton. The Arp2/3 complex nucleates formation of new actin filaments in response to activation of intracellular signaling systems.

The actin 2/3 complex (Arp2/3) regulates actin polymerization and nucleation of actin filaments, is associated with cell motility, and has been shown to play a key role in the invasion and migration of cancer cells. nucleation-promoting factor (NPF) such as N-WASP (neural-WASP famly verprolin-homologous protein family), WAVE (WASP famly ...

The actin-related protein (Arp) 2/3 complex uses the WASp as the first member of a family of actin nucleation-promoting factors (NPFs) to transfer surface cues to actin polymerization. The 502-amino acid protein that the WASP gene encodes includes 12 exons with 1823 base pairs and is primarily expressed in hematopoietic cells [15] .

2021年8月1日 · Here, we show that the actin-related protein (Arp)2/3 complex, a key factor in actin filament branching and polymerization, is involved in the shuttling of AQP2 between the trans-Golgi network (TGN) and the plasma membrane. Arp2/3 inhibition (using CK-666) or siRNA knockdown blocks vasopressin-induced AQP2 membrane accumulation and induces the ...

2020年12月22日 · Nature Communications - The actin-related protein (Arp)2/3 complex nucleates branched actin filament networks pivotal for cell migration, endocytosis and pathogen infection. Here, authors report...

As the first de novo actin nucleator discovered, the Arp2/3 complex has been a central player in models of protrusive force production via the dynamic actin network. Here, we review recent studies on the functional role of the Arp2/3 complex in the migration of diverse cell types in different migratory environments.

1999年2月1日 · Over the past two years, newly discovered properties of the Arp2/3 complex have suggested a central role in the control of actin polymerization. First, it promotes actin assembly on the surface of the motile intracellular pathogen Listeria monocytogenes. Second, it can nucleate and cross-link actin filaments in vitro.