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ARV-110 和 ARV-766 都是AR降解剂， ARV-110不能降解AR L702H突变，而ARV-766是泛AR降解剂，可以降解AR L702H突变，进一步增加患者人群范围。 ARV-766与ARV-110相比，在结构上主要有3处不同，包括将 中间的六元环改成取代的四元环，将左侧芳香环上氯原子替换成甲氧基以及将氟取代的沙利度胺替换为氟取代的苯甲酰胺，苯甲酰胺这一类CRBN配体有选择性高和血浆稳定性高等优点。 今年的 ESMO 会议上，ARV-766展示了非常好的临床1/2期活性，基于 …

2016年10月18日 · Avian reovirus (ARV) infections characterised by severe arthritis, tenosynovitis, pericarditis, and depressed growth have become increasingly frequent in recent years. In this...

2015年10月15日 · All of the 301 ARV isolates were confirmed by giant or “bloom-like” CPE-positive cells, which were subsequently stained positive for ARV by the fluorescent antibody (FA) test using a ...

Giant, or “bloom-like” CPE cells characteristic to ARV infections in BSR cell cultures (A). Immunofluorescence showed positive green fluorescence signals on ARV-infected cells (A).

2016年10月18日 · Avian reovirus (ARV) infections characterised by severe arthritis, tenosynovitis, pericarditis, and depressed growth have become increasingly frequent in recent years. In this study, we isolated and identified 11 ARV field strains from chickens with viral arthritis and reduced growth in northern China.

Avian reovirus (ARV) infections characterised by severe arthritis, tenosynovitis, pericarditis, and depressed growth have become increasingly frequent in recent years. In this...

2015年8月4日 · By using next-generation sequencing (NGS) technology, we have identified a divergent avian orthoreovirus (ARV) field variant (Reo/PA/Broiler/15511/13, or PA15511), isolated from broiler chickens with viral arthritis in Pennsylvania in 2013.

2024年5月3日 · Each of the 72 case specimens produced giant or bloom-like typical CPE characterized for ARV infection in the specimen-inoculated LMH monolayer cell cultures. The appearance of CPE varied from one-cell passage to 3∼4 serial passages.