2023年9月3日 · TLD adalah kombinasi tiga obat ARV, yaitu Tenofovir, Lamivudine, dan Dolutegravir. Dolutegravir adalah inhibitor integrase (INSTI), yang bekerja dengan cara mencegah virus HIV untuk bergabung dengan DNA sel inang.

TLD is a generic HIV combination. It contains tenofovir disoproxil, lamivudine and dolutegravir. Sometime the tablet are marked LTD. TLD is a very good combination and is now the most widely used ART. It is recommended by the WHO. This combination is only available in either low or middle-income countries.

The data on safety and efficacy of DTG-containing regimens were also reviewed, addressing key considerations associated with newer antiretroviral (ARV) drugs – including body weight gain and other cardiometabolic risks, tolerability of regimens, safety in pregnancy and HIV drug resistance.

TLD is a fixed-dose combination of TDF 300 mg, 3TC 300 mg, and DTG 50 mg. TLD is also recommended for use as a second-line regimen for patients failing on efavirenz- or nevirapine-containing regimens or for those failing a non-DTG-containing first-line regimen. WHY TRANSITION FROM TLE TO TLD?

2024年12月23日 · Secondary outcomes included viral suppression (< 50 copies/mL) and adverse drug reactions (ADRs). Using appropriate statistical tests, participant characteristics and outcomes were compared before and six months after transitioning. At baseline on TLE, 88% had viral suppression, and 3.6% had virologic failure.

What are dolutegravir and TLD? A. DTG is a relatively new ARV available in generic form in low- and middle-income countries. It is an integrase inhibitor that blocks an HIV enzyme (a protein that starts or increases the speed of a chemical reaction) called integrase.

This study explored the use of a single‐tablet regimen containing tenofovir disoproxil fumarate 300 mg + lamivudine 300 mg + efavirenz 400 mg (TLE400 STR) as a first‐line switch strategy in PWH in Pune, India. This retrospective cohort study was conducted in private sector ART clinics in three tertiary‐level hospitals in Pune, India.

2022年2月13日 · Konsep dasar penatalaksanaan HIV adalah penggunaan kombinasi anti retroviral (ARV). Kombinasi terdiri dari minimal dua nucleoside (and nucleotide) reverse transcriptase inhibitors (NRTIs) dan obat ketiga golongan lain. NRTIs contohnya tenofovir disoproxil fumarate (TDF), lamivudine (3TC), dan emtricitabine (FTC).

2024年4月24日 · Five criteria, namely, indication, dose, contraindication, drug interaction, and TLD safety monitoring were used to evaluate the appropriateness of TLD utilization. 80% of patients were transited to TLD from other regimens. The median time on TLD was found to be 13 months with 9 months to 18 months IQR.