AS03 (for "Adjuvant System 03") is the trade name for a squalene-based immunologic adjuvant used in various vaccine products by GlaxoSmithKline (GSK). It is used, for example, in GSK's A/H1N1 pandemic flu vaccine Pandemrix .

AS ( adjuvant System， AS) 佐剂是葛兰素史克 (Glaxo Smith Kline， GSK)公司研制的系列人用疫苗佐剂，分为 AS01、AS02、AS03 和 AS04。 AS01 脂质体佐剂. AS01 是由 MPL 和皂 QS-21 组成的复合佐剂,能够刺激基质细胞产生细胞因子,招募单核细胞和中性粒细胞，促进单核细胞分化成 树突状细胞，提高注射部位和引流淋巴结中树突状细胞的抗原递呈能力,辅助疫苗产生更高的适应性免疫反应。 AS01应用：疟疾疫苗Mosquirix佐剂及疱疹病毒疫苗Shingrix佐剂. AS01作用机制. …

AS03 is an Adjuvant System composed of α-tocopherol, squalene and polysorbate 80 in an oil-in-water emulsion. In various nonclinical and clinical studies, high levels of antigen-specific antibodies were obtained after administration of an AS03-adjuvanted vaccine, permitting antigen-sparing strategies.

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AddaS03™ is an oil-in-water nano-emulsion adjuvant, with a formulation similar to that of the adjuvant system AS03®, a fundamental component of pandemic influenza and protein-based covid vaccines [approved by relevant regulatory authorities] [1].

2023年10月12日 · AS ( adjuvant System， AS) 佐剂是葛兰素史克 (Glaxo Smith Kline， GSK)公司研制的系列人用疫苗佐剂，分为 AS01、AS02、AS03 和 AS04。 AS01 是由 MPL 和皂 QS-21 组成的复合佐剂,能够刺激基质细胞产生细胞因子,招募单核细胞和中性粒细胞，促进单核细胞分化成树突状细胞，提高注射部位和引流淋巴结中树突状细胞的抗原递呈能力,辅助疫苗产生更高的适应性免疫反应。 AS01应用：疟疾疫苗Mosquirix佐剂及疱疹病毒疫苗Shingrix佐剂. AS02是含有 …

AS03 is a squalene-based oil-in-water emulsion produced by GSK. It has been tested extensively in the clinic and is used for the H1N1 pandemic flu vaccine Pandemrix [112]. It is also in Arepanrix and the new Q-pan for H5N1 influenza [113]. Similar to MF59, AS03 can induce proinflammatory cytokines and chemokines, including CXCL10, but ...

The adjuvant system (AS) of GSK is the best example of this advancement to make an effective vaccine against malaria (80). How important is the delivery system for vaccine development? ...

AS03 是一种由 α-生育酚、角鲨烯和聚山梨醇酯 80 组成的水包油乳液的佐剂系统。 在各种非临床和临床研究中，在接种 AS03 佐剂疫苗后获得了高水平的抗原特异性抗体，从而允许采取抗原保留策略。 AS03 已被证明可以通过局部激活先天免疫系统和增加引流淋巴结中的抗原摄取和呈递来增强疫苗抗原特异性适应性反应，这一过程受 AS03 中 α-生育酚的存在调节。 在以 AS03 为佐剂的大流行前 H5N1 流感疫苗的非临床模型中，增加的抗流感抗体水平提供了针对与疫苗株同源和异 …

Effectiveness of the Sanofi/GSK (VidPrevtyn Beta) and Pfizer-BioNTech (Comirnaty Original/Omicron BA.4-5) bivalent vaccines against hospitalisation in England. AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans.