Activated Ask1-MKK4-p38MAPK/JNK stress signaling pathway in ... - PubMed
An Ask1-MKK4-p38MAPK/JNK pathway reflects adipocyte stress associated with adipose tissue inflammation, linking visceral adiposity to whole-body insulin resistance in obesity.
Activation of ASK1, downstream MAPKK and MAPK isoforms …
2010年9月1日 · Primary neonatal cardiac myocytes, infected with an adenoviral vector expressing wild-type ASK1 (ASK1) or empty vector (Con), were subjected to simulated ischaemia (black …
Apoptosis signal-regulating kinase 1 in stress and immune …
Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase (MAPK) kinase kinase of the c-Jun N-terminal kinase (JNK) and p38 MAPK pathways. ASK1 is preferentially …
Apoptosis Signal-regulating Kinase 1 (ASK1)-p38 Pathway …
2015年4月24日 · ASK1 is a stress-responsive MAP3K that acts as an upstream kinase of p38 and is activated by various stresses, such as oxidative stress. Here, we show that NR4A2, a …
Regulation of apoptosis signal-regulating kinase 1 by protein ...
ASK1 (apoptosis signal-regulating kinase 1), a MKKK (mitogen-activated protein kinase kinase kinase), is activated in response to cytotoxic stresses, such as H2O2 and TNFα (tumour …
Role of mitogen-activated protein kinase kinase kinases in signal ...
2007年5月14日 · ASK1 is the only MKKK with a thioredoxin-binding region that, although not a true ‘domain’, promotes apoptosis signal-regulating kinase (ASK1) specificity in responding to …
Redox Regulation of Cardiac ASK1 (Apoptosis Signal-Regulating …
2020年9月9日 · Redox-sensitive ASK1 (apoptosis signal-regulating kinase 1) activates stress-regulated protein kinases (p38-MAPK [mitogen-activated protein kinases] and JNKs [c-Jun N …
Structural and Functional Characterization of the Human Protein Kinase ASK1
2007年10月16日 · Apoptosis signal-regulating kinase 1 (ASK1, also called MAP3K5) is a mitogen-activated protein kinase kinase kinase (MAP3K) that plays an essential role in cellular stress …
Ginsenoside compound K alleviates brain aging by inhibiting …
2024年12月1日 · In summary, our research demonstrates that CK effectively delays brain aging by inhibiting the ASK1-MKK7-JNK signaling pathway, enhancing nuclear Nrf2 expression, and …
Stressed platelets ASK1 for a MAPK | Blood - American Society …
2017年3月2日 · ASK1 is a critical MAP3K in platelet activation. Physiological agonists acting through either G-protein-coupled receptors (GPCRs) or glycoprotein VI (GPVI) stimulate …