2019年4月15日 · We found a synthetic lethal interaction between activation of Wnt-dependent stabilization of proteins (Wnt/STOP) and asparaginase in acute leukemias resistant to this enzyme. Inhibition of the alpha isoform of GSK3 was sufficient to phenocopy this effect, and the combination of GSK3α-selective inhibitors and asparaginase had marked therapeutic ...

2022年6月23日 · Mechanically, ASNS modulated Wnt signal transduction by promoting GSK3β phosphorylation on ser9 and stabilizing the β-catenin complex, as result, ASNS could promote more β-catenin...

2024年9月17日 · ATF4 induces the transcription of asparagine synthetase (ASNS), which catalyzes asparagine (Asn) biosynthesis, facilitating osteosarcoma progression. Utilizing virtual screening, we identify paliperidone and AG-401 as potential NAT10 inhibitors, and both inhibitors are found to bind to NAT10 proteins.

We found a synthetic lethal interaction between activation of Wnt-dependent stabilization of proteins (Wnt/STOP) and as-paraginase in acute leukemias resistant to this enzyme.

2011年7月1日 · Elevated ATF4 activates many downstream genes including asparagine synthetase (ASNS) [4], ATF3 [5] and system A amino acid transporter 2 (SNAT2) [6]. Emerging evidence shows that the activation of the GCN2/ATF4 …

2021年7月1日 · With processing, ASNS possible interacted with key proteins located in Wnt/β-catenin signaling pathway to mediate signal conduction. But the activation of ASNS amidotransferase was necessary to promoted tumor proliferation.

2019年4月15日 · We found a synthetic lethal interaction between activation of Wnt-dependent stabilization of proteins (Wnt/STOP) and asparaginase in acute leukemias resistant to this enzyme. Inhibition of the alpha isoform of GSK3 was sufficient to phenocopy this effect, and the combination of GSK3α-selective inhibitors and asparaginase had marked therapeutic ...

The Slc7a5‐null phenotype is reminiscent of Wnt pathway mutants, and we show that Wnt/β‐catenin loss inhibits Slc7a5 expression and induces this stress response. Wnt signalling therefore normally supports the metabolic demands of …

ASNS was the gene most significantly depleted in asparaginase-treated cells, followed closely by NKD2 and LGR6 that encode two regulators of Wnt signaling (Figure 1B, Table S1). We prioritized Wnt signaling for further investigation because this was the only pathway known to be regulated by more than one gene among the top “hits” in our ...

2014年12月22日 · Indeed, DM-α-KG suppressed WNT3A-induced Gln consumption, phosphorylation of GCN2, and expression of protein anabolism genes (e.g., Asns) (Figure 5, E–G). Importantly, DM-α-KG severely impaired WNT-induced osteoblast differentiation, as indicated by the loss of mineralization activity (Figure 5 H).