2024年12月24日 · ATF6 (Activating Transcription Factor 6) is a Protein Coding gene. Diseases associated with ATF6 include Achromatopsia 7 and Achromatopsia. Among its related pathways are Unfolded Protein Response (UPR) and Alzheimer's disease and miRNA effects.

2024年3月15日 · Activating transcription factor 6 (ATF6), an important signaling molecule in unfolded protein response (UPR), plays a role in the pathogenesis of several diseases, including diseases such as congenital retinal disease, liver fibrosis and ankylosing spondylitis.

2018年5月25日 · Best known for its role in transducing signals linked to stress to the endoplasmic reticulum, the 50 kDa activated form of ATF6 is now emerging as a major regulator of organogenesis and tissue homeostasis.

Activating Transcription Factor - 6 (ATF-6) is a transmembrane glycoprotein of the endoplasmic reticulum (ER). Upon accumulation of improperly folded proteins in the ER, ATF-6 is cleaved liberating a 50 kDa amino-terminal fragment that translocates to the nucleus (1, 2).

2024年2月10日 · 激活转录因子 6 （ATF6） 是未折叠蛋白反应 （UPR） 中的重要信号分子，在多种疾病的发病机制中发挥作用，包括先天性视网膜疾病、肝纤维化和强直性脊柱炎等疾病。 内质网应激 （ERS） 后，ATF6 与内质网 （ER） 中的结合免疫球蛋白 （GRP78/BiP） 分离后被激活，并转运到高尔基体，被位点 1 和位点 2 蛋白酶水解成 ATF6 片段，ATF6 片段定位于细胞核并调节 ERS 相关基因的转录和表达。 在这些疾病中，ERS 导致 UPR 的激活，最终通过 ATF6 信 …

ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules. [8] Accumulation of misfolded proteins in the Endoplasmic Reticulum results in the proteolytic cleavage of ATF6. The cytosolic portion of ATF6 will move to the nucleus and act as a transcription factor to …

ATF6 is an ER type-II transmembrane protein with a N-terminal cytoplasmic region containing a bZIP and DNA transcription activation domain and a C-terminal lumenal region that senses ER stress. On activation of the UPR, ATF6 is processed to generate 50–60 kDa cytosolic bZIP-containing fragments (ATF6 (p50)) that migrate to the nucleus.

2012年4月1日 · ATF6 functions to increase ER capacity by stimulating transcription of ER-resident chaperone genes such as GRP78. Using an antibody that recognizes active ATF6α-p50, we found that active ATF6α was detected in insulinoma cells and rodent islets even under basal conditions and the levels were further increased by ER stress.

2016年5月9日 · ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecules (summary by Shen et al., 2002). An activating transcription factor (ATF)-binding site is a promoter element present in a wide range of viral and cellular genes.

2020年4月8日 · This cleavage liberates the N-terminal 50 kD cytosolic portion of ATF6, which has a nuclear localization sequence, facilitating its movement to the nucleus, where it acts as a transcription factor to induce genes that encode proteins that fortify the ER protein-folding environment (Figure 3C; Haze et al., 1999).