AuTophaGy related 1 (Atg1) is a 101.7kDa serine/threonine kinase in S.cerevisiae, encoded by the gene ATG1. [1] . It is essential for the initial building of the autophagosome and Cvt vesicles. In a non-kinase role it is - through complex formation with Atg13 and Atg17 - directly controlled by the TOR kinase, a sensor for nutrient availability.

2023年1月12日 · In recent years, much progress has been made in understanding the functions of individual ATG genes as well as their roles in disease and physiology. The molecular functions of key players have...

2019年1月10日 · The lysosomal degradation pathway of autophagy plays a fundamental role in cellular, tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy-related (ATG) genes. Definitive etiological links exist between mutations in genes that control autophagy and human disease, especially neurodegenerative, inflammatory ...

This study aimed to investigate the function and evolution of the ATG gene family in wheat and its diploid and tetraploid progenitors and to explore the role of TaVAMP727 in autophagy-related plant growth, development, and abiotic stress responses.

So, “ATG” and “Atg” are simply abbreviations for “autophagy-related.” If you want to say “autophagy-related gene” or “autophagy-related protein,” you can use “ ATG gene” or “Atg protein.”

2017年9月13日 · Autophagy is mediated by dozens of autophagy-related (Atg) proteins, among which Atg4 is the sole protease that regulates autophagy through the processing and deconjugating of Atg8. As the Atg4...

With the discovery of APG/ATG genes, functions of the gene products have been extensively studied, and details of the mechanism and physiological role of autophagy are being elucidated one after another. The 17 factors necessary for autophagosome formation which are marked with red circles above can be classified to 5 functional groups below;

To date, several key factors regulating this intracellular degradation process have been identified. The so-called autophagy-related (ATG) genes and proteins are central to this process. However, several additional molecules contribute to the outcome of an autophagic response.

2024年12月24日 · ATG3 (Autophagy Related 3) is a Protein Coding gene. Diseases associated with ATG3 include Neurodegeneration With Brain Iron Accumulation and Granulomatous Amebic Encephalitis. Among its related pathways are Autophagy and Selective autophagy.

Autophagy protein 5 (ATG5) is a protein that, in humans, is encoded by the ATG5 gene located on chromosome 6. It is an E3 ubi autophagic cell death. ATG5 is a key protein involved in the extension of the phagophoric membrane in autophagic vesicles. It is activated by ATG7 and forms a complex with ATG12 and ATG16L1.