细胞信号通路详解之ATM信号通路_Chk - 搜狐
2020年3月6日 · ATM是多个信号级联的关键调控因子，它对破坏性的IR(电离辐射)、辐射剂或正常过程引起的DNA链断裂做出响应。 这些反应包括激活细胞周期Chk因子 (检查点因子)、DNA …
The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer
In addition, suppressing DNA damage and replication checkpoint responses by inhibiting Chk1 can enhance tumor cell killing by diverse genotoxic agents. Here, we review current …
ATM 蛋白-DNA 损伤丨且看 ATM 激酶活化变单体后的神奇开挂！
ATM (Ataxia-telangiectasia mutated proteins) 是一种丝氨酸-苏氨酸蛋白激酶，是 DNA 损伤应答 (DDR) 的关键调节因子。 ATM 是位名副其实的“指挥官”，在 DNA 双链断裂 (DSB) 中，参与细 …
细胞周期通路 | Cell Signaling Technology
dna 损伤会通过 atm/atr 和 chk1/2 激酶激活反应通路来限制 cdk 活性，从而导致细胞周期停滞和 dna 修复或细胞死亡。 G2/M 检查点可防止带有受损 DNA 的细胞进入有丝分裂 (M) 阶段。
The ATM–Chk2–Cdc25A checkpoint pathway guards against
2001年4月12日 · Here we report a functional link between ATM, the checkpoint signalling kinase Chk2/Cds1 (Chk2) 12 and Cdc25A, and implicate this mechanism in controlling the S-phase …
EMBO J│曹流团队揭示DDR通路ATM-CHK2调控细胞自噬维系氧化 …
近期，中国医科大学曹流教授团队在Cell Death Differ杂志上发表题为SIRT1 modulates cell cycle progression through regulating CHK2 acetylation-phosphorylation的研究成果，探索了SIRT1 …
The ATM–Chk2 and ATR–Chk1 Pathways in DNA Damage
2010年1月1日 · Here, we review current understanding of the organization and functions of the ATM–Chk2 and ATR–Chk1 pathways and the prospects for targeting DNA damage signaling …
ATM signaling modulates cohesin behavior in meiotic prophase …
2023年3月6日 · We aligned the amino acid sequences of ATM family proteins and found a conserved CHK-2 consensus phosphorylation motif (R-X-X-S/T) within their FAT domains, …
ATM, ATR, CHK1, CHK2 and WEE1 inhibitors in cancer and cancer …
Herein, we review the inhibitors of five of the key regulators of the cell cycle checkpoints in cancer cells and in the particular settings of cancer stem cells: ATM and ATR, kinases that play apical …
ATM-CHK2-Beclin 1 axis promotes autophagy to maintain ROS
2020年5月18日 · Here, we show that reactive oxygen species (ROS) function as signaling molecules that regulate autophagy through ataxia-telangiectasia mutated (ATM) and cell cycle …