The P2X7 receptor: A main player in inflammation - PubMed
The P2X7R is an ATP gated ion channel, expressed by most immune cells, including the monocyte-derived cell lineages, T and B lymphocytes and their precursors. Here we give an …
P2X7受体及NLRP3炎性小体在炎症性疾病中的研究进展 - 中华微生 …
嘌呤能2X7受体 (purinergic 2X7 receptor, P2X7R)是一种离子通道型受体，可引起核苷酸结合寡聚化结构域样受体3 (nucleotide-binding oligomerization domain-like receptor protein 3, NLRP3) …
未来的成药新星-P2X7受体在多种疾病中的巨大潜力|电生理实验服 …
p2x受体主要被细胞外的 atp 激活开放，而p2x7由于对atp的亲和性较低而与其他家族中的受体略有差异。p2x7需要相较于生理浓度100-1000倍的胞外atp浓度才能被激活，据报道其ec50值为大 …
ATP-P2X7R轴在炎症性疾病中的作用 - rdbzz.com
本文就p2x7r所涉及的相关分子的基本概念、发现过程、主要来源及生理病理功能，以及atp-p2x7r信号通路及其在消化系统、呼吸系统、神经系统、免疫系统等常见炎症性疾病中的作用 …
Targeted P2X7/NLRP3 signaling pathway against inflammation
2022年4月12日 · Human retinal endothelial cells (hRECs) exposed to HG expressed high P2X7R levels, further, an effect amplified by treatment with 2′-3′-O-(4-benzoyl-benzoyl) ATP (BzATP), …
Paxillin mediates ATP-induced activation of P2X7 receptor …
2020年11月26日 · ATP directly activates the plasma membrane channel P2X7 receptor (P2X7R), leading to an intracellular influx of K +, a key trigger inducing NLRP3 inflammasome activation. …
Structural and Functional Basis for Understanding the Biological ...
The P2X7R activation requires large ATP release through nearby membrane structures such as the pannexin channel, but the precise balance of the extracellular ATP concentrations is also …
The P2X7 Receptor in Infection and Inflammation - Cell Press
Adenosine triphosphate (ATP) accumulates at sites of tissue injury and inflammation. Effects of extracellular ATP are mediated by plasma membrane receptors named P2 receptors (P2Rs). …
The P2X7 Receptor in Infection and Inflammation - ScienceDirect
2017年7月18日 · Adenosine triphosphate (ATP) accumulates at sites of tissue injury and inflammation. Effects of extracellular ATP are mediated by plasma membrane receptors …
ATP/P2X7r axis mediates the pathological process of allergic ... - PubMed
2020年1月1日 · ATP/P2X7r, expressed mainly on macrophages and dendritic cells, is associated with acute and chronic asthmatic airway inflammation and Th2 immune responses in mice and …