AZGP1 has been identified as a biomarker in cancer patients, with its role varying depending on the specific type of cancer. Low expression of AZGP1 is correlated with unfavorable outcomes in gastric cancer, esophageal squamous cell carcinoma, liver cancer, bladder cancer, and …

2024年12月24日 · AZGP1 (Alpha-2-Glycoprotein 1, Zinc-Binding) is a Protein Coding gene. Diseases associated with AZGP1 include Breast Cyst and Gastrointestinal System Cancer. Among its related pathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Miscellaneous transport and binding events.

2024年4月20日 · Here, we show that AZGP1 in POMC neurons plays a crucial role in controlling whole-body metabolism. POMC neuron-specific overexpression of Azgp1 under high-fat diet conditions reduces energy...

2024年5月1日 · azgp1正向调节瘦素-jak2-stat3信号传导并增加pomc神经元中的瘦素敏感性，从而促进体重减轻和能量消耗。 机制上，研究发现AZGP1通过与酰基甘油激酶（AGK）相互作用来阻止其泛素化降解，从而增强瘦素-JAK2-STAT3 信号通路。

2025年2月8日 · AZGP1 is androgen responsive and involved in AR-induced prostate cancer cell proliferation and metastasis. Cao R, et al. J Cell Physiol, 2019 Aug. PMID 30820960; Circulating zinc-α2-glycoprotein is reduced in women with polycystic ovary syndrome, but can be increased by exenatide or metformin treatment. Zheng S, et al. Endocr J, 2019 Jun 28.

2025年2月8日 · AZGP1 is a potential molecular marker for biochemical relapse in men with margin-positive, localized PC. AZGP1 identified as a biomarker candidate for chronic pancreatitis. The adipokine zinc-alpha2-glycoprotein activates AMP kinase in …

Zinc-α2-glycoprotein (ZAG), encoded by the AZGP1 gene, is a major histocompatibility complex I molecule and a lipid-mobilizing factor. ZAG has been demonstrated to promote lipid metabolism and glucose utilization, and to regulate insulin sensitivity.

本研究通过网络药理学和生物信息学方法发现azgp1是仑伐替尼治疗icc的潜在关键靶点。azgp1在icc中表达下调，其低表达提示预后不良。仑伐替尼对icc emt的影响是通过azgp1/tgf-β1/smad3通路介导的。最后，仑伐替尼可能通过增加azgp1启动子区h3k27ac水平来激活azgp1。

2024年11月15日 · AZGP1 regulates EMT and the focal adhesion pathway, which are vital protein interactors, thus promoting metastasis (Ji et al., 2023). Based on the conclusions of the aforementioned studies, we posited that AZGP1 might regulate COPD progression by mediating AT2 cell proliferation and adhesion.

Biased expression in salivary gland (RPKM 748.1), liver (RPKM 688.6) and 5 other tissues. 参与细胞粘附和检测参与苦味感官知觉的化学刺激。 位于细胞外空间。 [由基因组资源联盟提供，2022 年 4 月] Involved in cell adhesion and detection of chemical stimulus involved in sensory perception of bitter taste. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]