腺苷通过与免疫细胞上表达的 G蛋白偶联腺苷受体 （A1R、A2aR、A2bR、A3R）结合，介导和抑制多种免疫细胞（如T细胞、NK细胞、DC细胞等）的免疫响应能力。 其中A2aR是一种对腺苷具有高亲和力的典型G蛋白偶联受体，在T淋巴细胞、NK细胞、单核细胞和树突状细胞等免疫细胞上表达。 腺苷与A2aR受体结合激活典型的G蛋白并触发cAMP/PKA/CREB通路。 腺苷-A2aR通路在保护正常器官和组织免受免疫细胞自身免疫反应的影响方面发挥着重要作用。 然而，许多实体 …

2024年12月24日 · ADORA2A (Adenosine A2a Receptor) is a Protein Coding gene. Diseases associated with ADORA2A include Acute Encephalopathy With Biphasic Seizures And Late Reduced Diffusion and Basal Ganglia Disease. Among its related pathways are Signaling by NTRKs and Purinergic signaling.

2020年8月1日 · Various agents targeting A2AR or CD73 are currently being evaluated as cancer therapies in over 20 clinical trials (Table 1). These trials intend to evaluate the safety associated with blockade of adenosine production (via CD73) or adenosine signaling (via A2AR) and the downstream effects on anti-tumor immunity.

摘要: 2a型腺苷受体（A2aR）是一种广泛存在于各种免疫细胞表面的G蛋白偶联受体，与其配体腺苷（ADO）结合后发挥调控机体免疫功能的作用。 本文综述了A2aR在肿瘤免疫微环境抑制状态形成中的作用，为干预A2aR的临床应用提供资料。

储存条件 The product should be stored at - 8 5~ -6 5℃ for 1 year from date of receipt. Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles. 注意事项 Please operate with lab coats and disposable gloves, for your saf e ty. This product is for research use only. Ver. CN 202 40115

2022年3月21日 · Adenosine receptor, a GPCR, has been found in four categories: A1R, A2AR, and A3R with high affinity for adenosine, and A2BR with low affinity for adenosine (4 – 6). Among them, the A2AR is widely distributed on the surface of most immune cells (7 – 9).

2018年2月5日 · Adenosine is a nucleoside mainly formed by degradation of ATP, located intracellularly or extracellularly, and acts as a neuromodulator. It operates as a volume transmission signal through diffusion and flow in the extracellular space to modulate the activity of both glial cells and neurons.

配方 115mM Gly 4% 海藻糖 活动 酶联免疫吸附试验：固定化人 A2AR VLP 以 5 ug/mL（30 uL/孔）可结合 3F6-9G5（P57584），EC50 约为 0.02377 µg/ml。 应用 ELISA、动力学 (BLI)、动力学.

Adenosine Receptor Subtype A2a (A2aR) is a G-protein coupled receptor that mediates adenosine (a potent immunosuppressor) signaling in leukocytes. A2aR has been implicated in …

2016年7月27日 · Here we present the structure of the adenosine A 2A receptor (A 2A R) bound to an engineered G protein, mini-G s, at 3.4 Å resolution. Mini-G s binds to A 2A R through an extensive interface (1,048...