A molecular basis for the synergy between 17 ... - ScienceDirect
2019年2月5日 · 17-AAG mono-treatment in U251MG glioma cells showed a significant decrease in MMP-9 mRNA expression by inhibition of focal adhesion kinase (FAK) phosphorylation that is corroborated with our findings.
A molecular basis for the synergy between 17‑allylamino‑17
2019年2月5日 · Anti-proliferative, anti-metastatic and anti-angiogenic effects of 17‑allylamino‑17‑demethoxy geldanamycin (17-AAG) were studied alone and in combination with Capecitabine (Cap) and/or Irinotecan (IR) on HT-29 human colorectal carcinoma cells.
全面认识α1-酸性糖蛋白_血清 - 搜狐
2019年12月25日 · α1-酸性糖蛋白(α1-acidglycoprotein，AGP或AAG)，早期称之为血清类粘蛋白（Orosomucoid, ORM），是一种非特异性急性时相反应蛋白，也是人类血清中含糖量最多(含糖约45%)、酸性最强(PI为2.7～3.5)的糖蛋白。
Targeting Hsp90 with small molecule inhibitors induces the over ...
To determine whether the inhibition of Hsp90 with small molecule inhibitors was able to affect survivin expression, we treated human cancer cells with Hsp90 inhibitors geldanamycin and 17-AAG. 17-AAG is a selective Hsp90 inhibitor that exhibited therapeutic activities in various cancers and is currently undergoing phase III clinical trials [17 ...
Combination effects of capecitabine, irinotecan and 17-AAG on ...
NF-κB was down-regulated in single treatment and IR/Cap double combination group, significantly. 17-AAG mono-treatment and IR/Cap and Cap/17-AAG double combination group significantly upregulated p53 gene expression. Our findings showed proapoptotic effects of 17-AAG alone and in combination with Cap and IR.
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An HSP90 Inhibitor Overcomes FLT3 Inhibitor Resistance in …
2023年8月8日 · Using MOLM-13 (an AML cell line harboring FLT3-ITD), we established FLT3-selective inhibitor (FI-700)-resistant cell lines with an FLT3 N676K mutation. An HSP90 inhibitor (17-AAG) inhibited the growth of the cell lines, and combination treatment with FI-700 and 17-AAG showed synergistic inhibition.
Regulation of an adaptor protein STING by Hsp90β to enhance …
2020年10月1日 · Treatment with an Hsp90 inhibitor 17-AAG and knockdown of Hsp90β but not Hsp90α reduced STING at protein level, resulted in the suppression of IFN induction in response to stimulation with cGAMP, and infections with HSV-1 and Listeria monocytogenes. Collectively, our results suggest that the control of STING protein by Hsp90β is a critical ...
在 ADVIA Chemistry α1-Acid Glycoprotein (AAG) 检测中，样本被 稀释并与包含 α1-酸性糖蛋白特定抗体的缓冲液发生反应。在 发生反应期间形成抗体-抗原复合物，导致浊度增加，浊度水 平通过在 340 和 694 nm 下测量吸光度来确定。样本中的 α1-酸
Relationship between alpha 1-acid glycoprotein and plasma …
The unbound fraction of DP and MND in highly purified serum alpha 1-acid glycoprotein (AAG) at 0.5 g/l was 57 and 62 and at 2.0 g/l 19 and 30% respectively. Unbound DP and MND were measured in spiked plasma (10 mumol/l of DP or MND), from 60 patients, having AAG concentrations varying from 0.4 to 3.0 g/l.