Aralkylamine N-acetyltransferase (AANAT) (EC 2.3.1.87), also known as arylalkylamine N-acetyltransferase or serotonin N-acetyltransferase (SNAT), is an enzyme that is involved in the day/night rhythmic production of melatonin, by modification of serotonin.

2024年12月24日 · AANAT (Aralkylamine N-Acetyltransferase) is a Protein Coding gene. Diseases associated with AANAT include Delayed Sleep Phase Disorder and Nystagmus 6, Congenital, X-Linked. Among its related pathways are Biogenic amine synthesis and superpathway of tryptophan utilization.

AANAT is a gene that encodes an enzyme aralkylamine N-acetyltransferase. [5] It is the key regulator of day-night cycle (circadian rhythm). It is found in all animals. In humans it is present on chromosome 17, in chimpanzees chromosome 17, in mouse and sheep chromosome 11, in rat chromosome 10, and in chicken chromosome 18. [6]

AANAT（aralkylamine N-acetyltransferase，芳烷胺N-乙酰转移酶）是体内一种可以通过修饰 5-羟色胺 而参与褪黑激素产生的酶。 研究人员利用基因技术敲除小鼠体内的AANAT基因，使褪黑素的产生受损，发现这种基因缺陷小鼠的大脑和初级脑皮质神经元中线粒体 氧化应激 ...

在脊椎动物中，芳烷基胺N-乙酰转移酶（AANAT；EC 2.3.1.87）是褪黑激素 (Mel) 生物合成中的计时酶和关键调节酶。 AANAT 存在于松果体、视网膜和其他区域，受光、环磷酸腺苷 (cAMP) 水平和分子钟控制。 AANAT 将血清素转化为N-乙酰基血清素 (NAS)，途径中的最后一种酶羟邻甲基转移酶 (HIOMT) 通过 NAS 甲基化形成 Mel。 我们之前已经证明 AANAT 在白天在鸡视网膜神经节细胞 (RGC) 中以 mRNA 和酶活性水平表达。 在这里，我们研究了鸡胚视网膜整个发育过程 …

该基因编码的蛋白质属于乙酰转移酶超家族。 它是褪黑激素合成中的倒数第二个酶，控制脊椎动物松果体中褪黑激素产生的昼夜节律。 褪黑激素对于影响活动和睡眠的生物钟功能至关重要。 这种酶受 cAMP 依赖性磷酸化的调节，促进其与 14-3-3 蛋白的相互作用，从而保护该酶免受蛋白酶体降解。 该基因可能导致许多遗传疾病，例如延迟睡眠期综合症。 已发现该基因编码不同亚型的可变剪接转录物变体。 [RefSeq 提供，2009 年 10 月] The protein encoded by this gene …

2019年6月20日 · Aanat (aralkylamine N -acetyltransferase), a rate-limiting enzyme for melatonin production, was found to mostly localize in the mitochondria. Aanat knockdown significantly impeded embryonic development, and melatonin supplementation rescued it.

2025年2月8日 · The two most significant genes were NPAS2 (pgene = 0.0062) and AANAT (pgene = 0.00078); the latter being significant after Bonferroni correction. Data show that arylalkymine N-acetyltransferase (AANAT) levels and melatonin synthesis change after transient receptor potential channel 4 (TRPV4 channel) stimulation in ciliary body epithelial cells.

2021年8月23日 · Arylalkylamine N-acetyltransferase (AANAT) plays a crucial role in synchronizing internal biological functions to circadian and circannual changes. Generally speaking, only one copy of AANAT gene has been found in mammals, however, three independent duplications of this gene were detected in several …

Arylalkylamine N-acetyltransferase (AANAT) plays a crucial role in synchronizing internal biological functions to circadian and circannual changes. Generally speaking, only one copy of AANAT gene has been found in mammals, however, three independent ...