Divergent engagements between adeno-associated viruses …
2019年8月21日 · Adeno-associated virus (AAV) receptor (AAVR) is an essential receptor for the entry of multiple AAV serotypes with divergent rules; however, the mechanism...
AAVR: A Multi-Serotype Receptor for AAV - Cell Press
Adeno-associated virus (AAV) continues to be a promising viral vector for delivery of therapeutic genes in human gene therapy. In 2012, the European Commission approved Glybera …
Comprehensive biophysical characterization of AAV-AAVR …
2023年9月20日 · Universal AAV receptor (AAVR) has been identified to be involved in cellular entry of different AAV serotypes. With the unveiling of the high-resolution AAV-AAVR complex …
An essential receptor for adeno-associated virus infection
2016年2月4日 · We show that AAVR directly binds to AAV2 particles, and that anti-AAVR antibodies efficiently block AAV2 infection. Moreover, genetic ablation of AAVR renders a wide …
腺相关病毒（AAV）细胞进入：结构性见解 - 搜狐
2024年10月20日 · 高分辨率冷冻电子显微镜（cryo-EM）结构详细说明了腺相关病毒（AAV）受体蛋白的结合相互作用。AAV的糖基“主要受体”被重新定义为“附着因子”。AAV5类病毒与受体的 …
An essential receptor for adeno-associated virus infection
2016年1月27日 · We show that AAVR directly binds to AAV2 particles, and that anti-AAVR antibodies efficiently block AAV2 infection. Moreover, genetic ablation of AAVR renders a wide …
Adeno-associated virus 2 bound to its cellular receptor AAVR
2019年2月11日 · The structure of adeno-associated virus (AAV) type 2 in complex with its receptor, AAVR, provides new insights on the molecular mechanism of AAV entry into host …
Structural and cellular biology of adeno-associated virus attachment ...
2020年1月1日 · Binding of AAV to AAVR is critical for efficient transduction. AAV transduction can be blocked by addition in the medium of AAVR-specific antibodies or soluble AAVR. AAVR is a …
AAVR Expression is Essential for AAV Vector Transduction in …
2025年1月7日 · In this study, we demonstrated that expression of a key AAV receptor (AAVR, Kiaa0319l, or Au040320) in OHCs and vestibular hair cells decreases significantly in mature …
经验分享：腺相关病毒（AAV）受体研究进展简介 - 搜狐
2023年3月20日 · 腺相关病毒 (Adeno-associated virus, AAV) 是一类无被膜、具有二十面体结构、直径20~26nm之间、含有4.70kb线性单链DNA基因组的细小病毒 [1]。AAV载体具有体内表达 …