Human cell based directed evolution of adenine base editors …
2021年10月8日 · Adenine base editors (ABE) are genome-editing tools that have been harnessed to introduce precise A•T to G•C conversion. However, the low activity of ABE at...
In vivo adenine base editing of PCSK9 in macaques reduces LDL ...
2021年5月19日 · Most known pathogenic point mutations in humans are C•G to T•A substitutions, which can be directly repaired by adenine base editors (ABEs). In this study, we investigated …
A precise and efficient adenine base editor - ScienceDirect
2022年9月7日 · NG-ABE9e exhibits robust and precise base-editing activity in human cells, with more than 7-fold bystander editing reduction at some sites, compared with NG-ABE8e. To …
Efficient generation of mouse models of human diseases via ABE …
2018年6月14日 · Here we achieve A-to-G conversion in vivo at frequencies up to 100% by microinjection of ABE mRNA together with sgRNAs. We then generate mouse models …
Adenine base editor-mediated splicing remodeling activates
Adenine base editors (ABEs) are genome-editing tools that have been harnessed to introduce precise A•T to G•C conversion. The discovery of split genes revealed that all introns contain …
A precise and efficient adenine base editor - PubMed
2022年9月7日 · We identify a novel variant (NG-ABE9e), which harbors nine mutations. NG-ABE9e exhibits robust and precise base-editing activity in human cells, with more than 7-fold …
大幅提高安全性，谷峰/张金伟/高彩霞合作开发精准高效碱基编辑器|编辑|碱基|编辑器|NG-ABE…
2022年8月2日 · 碱基编辑器 （Base Editor）通过基因组 DNA 中的单核苷酸转换实现精确的基因校正，而无需产生DSB，从而克服了 CRISPR 系统的许多限制，然而 脱靶效应 和 旁观者效应 …
Human cell based directed evolution of adenine base editors with ...
2021年10月8日 · Adenine base editors (ABE) are genome-editing tools that have been harnessed to introduce precise A•T to G•C conversion. However, the low activity of ABE at certain sites …
Feng-Hao Liu
Leakage-Resilient IBE/ ABE with Optimal Leakage Rates from Lattices with Qiqi Lai, Feng-Hao Liu, and Zhedong Wang PKC 2022; Ring-based identity based encryption – asymptotically …
Adenine base editor–mediated splicing remodeling activates …
2023年12月1日 · Adenine base editors (ABEs) are genome-editing tools that have been harnessed to introduce precise A•T to G•C conversion. The discovery of split genes revealed …