2022年12月1日 · Here, we demonstrated that plasma p-tau231 and plasma Aβ42/40 significantly changed at lower threshold of PET centiloids (Fig. 1 and Extended Data Table 6) and CSF Aβ42/40 levels (Extended Data...

β淀粉样蛋白多肽42 (Aβ42)细丝的组装是阿尔茨海默病的核心事件。 研究者们在三例 散发性阿尔茨海默病 人（sporadic Alzheimer’s disease, sAD）和两例家族性阿尔茨海默（familial Alzheimer’s disease, fAD，编码 V717F 的 APP 突变和编码 F105L 的 PSEN1 突变）病人中发现I 型和II 型两种类型的Aβ42蛋白纤维（图二）。 图二. 经过冷冻电镜结构结构解析，发现它们各由两个‘S’形原丝以“面对面”、“背对背”的作用方式螺旋堆积而成。 同时，研究者们在对其他疾病的研究中，也发 …

During the last 20 years, an expanding body of research has elucidated the central role of amyloid precursor protein (APP) processing and amyloid beta peptide (Abeta) production in the risk, onset, and progression of the neurodegenerative disorder Alzheimer's disease (AD), the most common form of dementia.

An Abeta42 result greater than 834 pg/mL is associated with a reduced likelihood that a patient's cognitive impairment is due to AD. Total Tau (t-Tau) and phosphorylated Tau (p-Tau181) cerebrospinal fluid (CSF) concentrations increase approximately 2 to 3-times as much in patients with mild-moderate AD as compared to age-matched controls.

Tau protein and amyloid beta 42 peptide test, Alzheimer disease biomarkers. What is this test? This test examines proteins in the cerebrospinal fluid (CSF) to aid health care providers in diagnosing Alzheimer disease and distinguishing it from other forms of dementia.

血浆Aβ蛋白42/Aβ蛋白40 (Aβ42/Aβ40)是一种检测淀粉样斑块的可靠方法，可用于辅助诊断AD，识别那些未来因AD而患痴呆症的风险人群，并提高参与AD研究和临床试验的人群的多样性。 这项研究提供了第二类证据，即血浆Aβ42/Aβ40，通过高精度的IPMS测定，可以准确地诊断认知正常和受损的研究参与者的脑淀粉样变性。 文献来源： Li Y, Schindler SE, Bollinger JG, et al. Validation of Plasma Amyloid-β 42/40 for Detecting Alzheimer Disease Amyloid Plaques [published online …

2003年1月7日 · Of particular relevance for elucidating the role of Abeta in AD is new evidence that oligomeric forms of Abeta are potent neurotoxins that play a major role in neurodegeneration and the strong association of the 42-residue form of Abeta, Abeta42, with the disease.

Among all kinds of Aβ isoforms, Aβ40 and Aβ42 are believed to be the most important ones. Although these two kinds of Aβ differ only in two amino acid residues, recent studies show that they differ significantly in their metabolism, physiological functions, toxicities, and …

研究发现，Aβ42通过一个二次成核的自催化过程在纤维的表面发生聚集 【5-6】。 然而，在 淀粉样纤维 的形成过程中，驱动细胞毒性低聚物动态的具体分子机制，我们仍然未知。

2021年7月2日 · 骆静辉团队提出的这种新的单个 Aβ42 寡聚体可以有助于更好地理解脂质膜中淀粉样蛋白寡聚体的结构和动力学，从而对寡聚体毒性的分子机制产生新的见解。 同样也有助于理解脂质膜中的膜蛋白寡聚化，特别是关于形成离子通道的β-折叠蛋白。 αHL 展示的寡聚体作为模拟抗原，具有明确定义的化学计量，可能允许开发新的、构象特异性抗体。 这将允许开发基于免疫诊断方法的替代方法，甚至可能用于 阿尔兹海默症和其他神经退行性疾病的治疗。 这一成果近期发 …