2024年12月24日 · ABHD5 (Abhydrolase Domain Containing 5, Lysophosphatidic Acid Acyltransferase) is a Protein Coding gene. Diseases associated with ABHD5 include Chanarin-Dorfman Syndrome and Ichthyosis. Among its related …

1-acylglycerol-3-phosphate O-acyltransferase ABHD5, also known as comparative gene identification-58 (CGI-58), [5] is an enzyme that in humans is encoded by the ABHD5 gene. [6][7]

We recently identified synthetic ligands of α-β-hydrolase domain containing 5 (ABHD5) that directly activate adipose triglyceride lipase (ATGL) by dissociating ABHD5 from its inhibitory regulator, perilipin-1 (PLIN1).

由该基因编码的蛋白质属于由 alpha/beta 水解酶折叠定义的一大类蛋白质，并且包含三个序列基序，对应于酯酶/脂肪酶/硫酯酶亚家族中发现的催化三联体。 它不同于该亚科的其他成员，因为它假定的催化三联体含有天冬酰胺而不是丝氨酸残基。 该基因的突变与 Chanarin-Dorfman 综合征有关，Chanarin-Dorfman 综合征是一种甘油三酯贮积病，长链脂肪酸氧化受损。 [RefSeq 提供，2008 …

2017年2月17日 · Alpha-beta hydrolase domain-containing 5 (ABHD5), the defective gene in human Chanarin-Dorfman syndrome, is a highly conserved regulator of adipose...

2022年2月16日 · Alpha/beta hydrolase domain-containing protein 5 (ABHD5) is a highly conserved protein that regulates various lipid metabolic pathways via interactions...

The α/β-Hydrolase domain-containing protein 5 (ABHD5; also known as comparative gene identification-58, or CGI-58) is the causative gene of the Chanarin-Dorfman syndrome (CDS), a disorder mainly characterized by systemic triacylglycerol accumulation ...

2025年2月8日 · Reduced expression of the metabolic enzyme ABHD5 in macrophages promotes cancer metastasis. ABHD5 is a potential therapeutic target against metastatic castration-resistant prostate cancer. The results here report on three patients with mutations in the ichthyosis-related gene, ABHD5 involved in lipid metabolism, presenting with erythrokeratoderma.

The ABHD5 gene provides instructions for making a protein that turns on (activates) an enzyme called adipose triglyceride lipase (ATGL). Learn about this gene and related health conditions.

2015年11月3日 · Fat and muscle lipolysis involves functional interactions of adipose triglyceride lipase (ATGL), α-β hydrolase domain-containing protein 5 (ABHD5), and tissue-specific perilipins 1 and 5 (PLIN1 and PLIN5). ABHD5 potently activates ATGL, but this lipase-promoting activity is suppressed when ABHD5 is bound to PLIN proteins on lipid droplets.