2024年12月24日 · ABI3BP (ABI Family Member 3 Binding Protein) is a Protein Coding gene. Diseases associated with ABI3BP include Microphthalmia. Gene Ontology (GO) annotations related to this gene include heparin binding and glycosaminoglycan binding. An important paralog of this gene is FNDC1.

2025年2月8日 · ABI3BP is a susceptibility gene for Kashin-Beck disease in the Chinese Han population. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) These results suggest that TARSH plays an important role in proliferation of replicative senescence and may serve as a trigger of tumor development.

2019年3月14日 · ABI3BP is a relatively newly identified protein whose general biological functions are not yet fully defined. It is implicated in promoting cellular senescence and cell-extracellular matrix interactions, both of which are of vital importance in the cardiovascular system. ABI3BP has been shown in mul …

2019年3月13日 · ABI3BP is a relatively newly identified protein whose general biological functions are not yet fully defined. It is implicated in promoting cellular senescence and cell-extracellular matrix interactions, both of which are of vital importance in the cardiovascular system.

2023年5月1日 · ABI Family Member 3 Binding Protein (ABI3BP) is an extracellular matrix protein that affects the carcinogenesis of lung and esophageal cancer. However, the relevance of ABI3BP in different forms of cancer is uncertain.

预测启用肌动蛋白丝结合活性和糖胺聚糖结合活性。 预计参与肌动蛋白细胞骨架重组的调控；树突棘形态发生的调节；和突触后密度组装的调节。 预计在细胞外基质组织的上游或细胞外基质组织内起作用，并积极调节细胞-基质粘附。 位于细胞外空间。 与含胶原蛋白的细胞外基质共定位。 [由基因组资源联盟提供，2022 年 4 月] Predicted to enable actin filament binding activity and glycosaminoglycan binding activity.

2023年5月1日 · Abnormal expression of ABI3BP accurately predicts the prognosis of patients with renal chromophobe carcinoma (KICH), mesothelioma (MESO), and pancreatic adenocarcinoma (PAAD). Meanwhile, aberrant expression of ABI3BP was associated with immune checkpoints, TMB, MSI, tumor purity, HRD, LOH, and drug sensitivity.

2025年1月4日 · Title: Long noncoding RNA MALAT1 potentiates growth and inhibits senescence by antagonizing ABI3BP in gallbladder cancer cells. ABI3BP is a susceptibility gene for Kashin-Beck disease in the Chinese Han population.

Cardiac progenitor cells (CPCs) are believed to differentiate into the major cell types of the heart; cardiomyocytes, smooth muscle cells, and endothelial cells. We have recently identified Abi3bp as a protein important for mesenchymal stem cell ...

Abi3bp formed extracellular deposits with expression controlled by Akt1 and ubiquitin-mediated degradation. Abi3bp knockdown/knockout stabilized focal adhesions and promoted stress-fiber formation. Furthermore, MSCs from Abi3bp knockout mice displayed severe deficiencies in osteogenic and adipogenic differentiation.