2025年1月22日 · In neonates with a maternal blood incompatibility (eg, Rh, non-Rh, or ABO) and laboratory findings of hemolysis, a positive DAT is diagnostic of HDFN. If the DAT is negative, an indirect antiglobulin test is recommended for diagnostic support since some incompatibilities (eg, ABO) are not as reliably excluded by DAT.

The clinical course of ABO HDFN is relatively benign, characterized by high serum bilirubin, moderately severe anemia, reticulocytosis and spherocytosis. Hydrops caused by ABO-HDFN is extremely rare, and very occasionally exchange transfusion …

Hemolytic disease of the newborn (HDN) used to be a major cause of fetal loss and death among newborn babies. The first description of HDN is thought to be in 1609 by a French midwife who delivered twins—one baby was swollen and died soon after birth, the other baby developed jaundice and died several days later.

2015年12月5日 · Hemolytic disease of the fetus and newborn (HDFN) is rare condition that occurs when maternal red blood cell (RBC) or blood group antibodies cross the placenta during pregnancy and cause fetal red cell destruction. The fetal physiological consequences of severe anemia in the fetus can also lead to edema, ascites, hydrops, heart failure, and death.

ABO incompatibility and other alloantibodies have emerged as a significant cause of hemolytic disease of fetus and newborn (HDFN), leading to neonatal morbidity and mortality. We report three cases of severe ABO-HDFN where blood exchange transfusions (ETs) were required in neonates with hyperbilirubinemia.

Hemolytic disease of the fetus and newborn (HDFN) is a blood disorder that causes a baby’s red blood cells to break down quickly (hemolysis). HDFN occurs when there is a mismatch between the mother’s and baby’s blood type and/or Rh factor during pregnancy.

With routine immunoprophylaxis with Rh IG, ABO incompatibility is now the single largest cause of HDFN in the western world. ABO hemolytic disease occurs almost exclusively in infants of blood group A or B born to O group mothers, because Ig G anti A, anti B, occur more commonly in group O than group A or B individuals.

【摘要】 针对国际上对胎儿新生儿溶血病（hemolytic disease of the fetus and newborn，HDFN）的发病机制、实验室诊 断和治疗研究取得的进展，中国输血协会免疫血液学专业委员会组织专家根据国内前期调研 HDFN 实验室的具体发展现状，

2024年5月6日 · Maternal-fetal incompatibility with ABO, Rhesus factor (Rh) and/or other red blood cell antigens, RhD, Kell, and other non-ABO alloantibodies are the primary cause of moderate to severe HDFN, whereas ABO HDFN is typically mild and occurs after birth. If untreated or if not treated quickly, HDFN can progress to hydrops, organ failure and death.

2023年10月17日 · Severe cases of HDFN have been reported based on ABO incompatibility; particularly at risk are mothers who are secretors and develop very high titers of anti-B .