2024年12月24日 · ACAA1 (Acetyl-CoA Acyltransferase 1) is a Protein Coding gene. Diseases associated with ACAA1 include Immunodeficiency 68 and Chondrodysplasia Punctata Syndrome. Among its related pathways are Peroxisomal lipid metabolism and Fatty acid metabolism.

Acetyl-Coenzyme A acyltransferase 1 is an acetyl-CoA C-acyltransferase enzyme. This gene encodes an enzyme operative in the beta oxidation system of the peroxisomes. [5] Deficiency of this enzyme leads to pseudo- Zellweger syndrome. [5] ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

摘要 乙酰辅酶a酰基转移酶1(acaa1)基因编码硫解酶家族的酶,属于酰基辅酶a代谢酶超家族中的硫解酶家族。acaa1分布在过氧化物酶体中,通过催化β-氧化途径的最后一步参与脂肪酸的延伸和降解,是细胞脂代谢过程中一个重要调控基...

2025年2月8日 · Inhibition of ACAA1 Restrains Proliferation and Potentiates the Response to CDK4/6 Inhibitors in Triple-Negative Breast Cancer. A novel missense variant in ACAA1 contributes to early-onset Alzheimer's disease, impairs lysosomal function, and facilitates amyloid-beta pathology and cognitive decline.

乙酰辅酶a酰基转移酶1(acaa1)基因编码硫解酶家族的酶,属于酰基辅酶a代谢酶超家族中的硫解酶家族.acaa1分布在过氧化物酶体中,通过催化β-氧化途径的最后一步参与脂肪酸的延伸和降解,是细胞脂代谢过程中一个重要调控基因.本文综述了acaa1基因的结构,表达,分子 ...

ACAA1 is an enzyme involved in lipid β-oxidation and provides substrates to the tricarboxylic acid (TCA) cycle, a critical step in cellular metabolism. ACAA1 is also a biomarker in type 2 diabetes (T2D), predicting the pre-diabetic metabolic signature in mouse models . Nwosu et al. observed that up-regulated activity of MAPK/RAS/NFκB ...

Broad expression in liver (RPKM 125.0), kidney (RPKM 97.3) and 24 other tissues. 该基因编码一种在过氧化物酶体的 β 氧化系统中起作用的酶。 这种酶的缺乏会导致假齐薇格综合征。 可变剪接导致多个转录本变体。 [RefSeq 提供，2008 年 7 月] This gene encodes an Enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this Enzyme leads to pseudo-Zellweger syndrome.

2024年12月26日 · 本文将详细介绍ACAA1基因的功能与作用机制，包括其在细胞代谢中的角色、信号通路中的位置、以及与某些疾病的可能关联。 ACAA1基因，全称为 acetyl-CoA acyltransferase 1，位于人类染色体3p22.2位置。 这个基因编码的蛋白质在细胞代谢中扮演着关键角色，特别是在脂肪酸和酮体的代谢过程中。 ACAA1主要负责催化 乙酰辅酶A （acetyl-CoA）与 长链脂肪酸 （long-chain fatty acids）之间的反应，生成 乙酰辅酶A酯。 这个过程是脂肪酸代 …

2020年10月22日 · Here, we analyzed the differential expression of acetyl-CoA acyltransferase 1 (ACAA1) in various types of cancers using the TIMER database and validated the results in the NSCLC cell line H1944. We silenced oncogenic KRAS by siRNA targeting KRAS G13D, and employed an MAPK signaling pathway inhibitor to clarify the possible regulatory pathway.

Further in vitro and in vivo evidence showed that ACAA1 p.N299S contributes to AD by disturbing its enzymatic activity, impairing lysosomal function, and aggravating the A pathology and neuronal...