2024年12月24日 · ACADL (Acyl-CoA Dehydrogenase Long Chain) is a Protein Coding gene. Diseases associated with ACADL include Bardet-Biedl Syndrome 18 and Acyl-Coa Dehydrogenase, Very Long-Chain, Deficiency Of . Among its related pathways are Fatty acid metabolism and Mitochondrial Fatty Acid Beta-Oxidation .

Acadl is a single-copy, nuclear encoded gene approximately 35 kb in size. The gene contains 11 coding exons ranging in size from 67 bp to 275 bp, interrupted by 10 introns ranging in size from 1.0 kb to 6.6 kb in size. The Acadl 5' regulatory region, like other members of the Acad family, lacks a TATA or CAAT box and is GC rich.

这种蛋白质是催化直链脂肪酸线粒体 β-氧化初始步骤的四种酶之一。 该基因的缺陷是长链酰基辅酶 A 脱氢酶 (LCAD) 缺乏的原因，可导致非酮症性低血糖。 [RefSeq 提供，2008 年 7 月] The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism.

2020年3月25日 · Long-chain acyl-CoA dehydrogenase (ACADL) is a mitochondrial enzyme that catalyzes the initial step of fatty acid oxidation, but the role of ACADL in tumor...

2025年1月4日 · Long-chain acyl-CoA dehydrogenase is a key enzyme in the mitochondrial beta-oxidation of unsaturated fatty acids. Lea W, Abbas AS, Sprecher H, Vockley J, Schulz HLea W, et al. Biochim Biophys Acta, 2000 May 31. PMID 10832093.

2025年2月8日 · Bulk and single-cell transcriptome profiling reveal extracellular matrix mechanical regulation of lipid metabolism reprograming through YAP/TEAD4/ACADL axis in hepatocellular carcinoma. ACADL suppresses PD-L1 expression to prevent cancer immune evasion by targeting Hippo/YAP signaling in lung adenocarcinoma.

2023年3月17日 · Long-chain Acyl-CoA dehydrogenase (ACADL), a key enzyme that regulates β-oxidation of long-chain fatty acyl-CoAs, has been found to act as a tumor suppressor in cancers. However, the role of ACADL in lung adenocarcinoma (LUAD) has not been explored.

2023年11月27日 · ACADL（Acyl-CoA Dehydrogenase, Long Chain）重组蛋白是研究细胞能量代谢和相关疾病的重要工具。 这种酶在长链脂肪酸的β-氧化过程中发挥关键作用，对于维持能量平衡和健康状态至关重要。

使用sa的生物素衍生物，酰基辅酶a脱氢酶长链（acadl）被确定为sa及其衍生物的目标蛋白。有人提出sa及其衍生物可能通过acadl抑制脂肪酸的β-氧化，脂肪酸在巨噬细胞上的积累会抑制核因子-κb（nf-κb）信号通路和inos表达，从而具有抗炎活性。

参与使用酰基CoA脱氢酶的长链脂肪酸β氧化和长链脂肪酸代谢过程。 位于线粒体基质和线粒体膜上。 与人类ACADL（酰基CoA脱氢酶长链）正链同源。 [由基因组资源联盟，2022年4月提供] 该基因暂未发现相关的转录本和蛋白质序列信息。 Functional annotation of a full-length mouse cDNA collection. Analysis of the mouse transcriptome based …