2024年12月24日 · ACKR1 (Atypical Chemokine Receptor 1 (Duffy Blood Group)) is a Protein Coding gene. Diseases associated with ACKR1 include White Blood Cell Count Quantitative Trait Locus 1 and Malaria. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

Duffy antigen/chemokine receptor (DARC), also known as Fy glycoprotein (FY) or CD234 (Cluster of Differentiation 234), is a protein that in humans is encoded by the ACKR1 gene. [5] [6] [7] The Duffy antigen is located on the surface of red blood cells, and is named after the patient in whom it was discovered.

2022年9月9日 · 非造血细胞至少表达四种非典型性趋化因子受体，包括 ackr1、ackr2、ackr3 和 ackr4，它们的功能主要包括： ACKR1/DARC： 由红细胞、内皮细胞和胎盘滋养层细胞表达。

2025年1月10日 · ACKR1/DARC：由红细胞、内皮细胞和胎盘滋养层细胞表达。 血管内皮细胞上表达的ACKR1能够诱导趋化因子在血管内皮细胞管腔表面的聚集，从而增加白细胞渗出。 而红细胞上表达的ACKR1则能够调节循环趋化因子浓度的变化。 ACKR2/D6：由淋巴管内皮细胞、胎盘滋养细胞和一些白细胞表达。 ACKR2作为趋化因子清道夫受体，将趋化因子转运到细胞内进行降解，从而抑制炎症。 ACKR2在癌症中的功能具有双重性，既可能抑制肿瘤发展，也可能促进 …

2025年3月8日 · Single-cell Transcriptomic Analysis Reveals an Immunosuppressive Network Between POSTN CAFs and ACKR1 ECs in TKI-resistant Lung Cancer. Structural basis for DARC binding in reticulocyte invasion by Plasmodium vivax. Endothelial ACKR1 is induced by neutrophil contact and down-regulated by secretion in extracellular vesicles.

Atypical chemokine receptor 1 (ACKR1), previously known as the Duffy antigen receptor for chemokines (DARC), is a key regulator that binds chemokines involved in inflammatory responses and cancer proliferation, angiogenesis, and metastasis.

2024年12月22日 · ackr1作为非典型性趋化因子受体蛋白，具有与多种趋化因子结合的独特能力，促进它们的清除或穿胞作用。基因功能分析揭示了ackr1 hi ecs对于白细胞跨越血管壁的迁移至关重要，强调了ackr1在炎症反应中的作用。

2013年10月11日 · ACKR1 has been regarded as an essential receptor on erythrocytes for P. vivax but recent work suggests that there are ACKR1-independent invasion pathways (reviewed in Ref. 100).

2024年9月24日 · Genome-wide association replicates the association of Duffy antigen receptor for chemokines (DARC) polymorphisms with serum monocyte chemoattractant protein-1 (MCP-1) levels in Hispanic children. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

非典型趋化因子受体 1 (达菲血型)： 该基因编码的蛋白质是一种糖基化膜蛋白，是几种趋化因子的非特异性受体。 编码的蛋白质是人类疟疾寄生虫间日疟原虫和诺氏疟原虫的受体。 该基因的多态性是达菲血型系统的基础。 已发现该基因的两个转录本变体编码不同的亚型。 [RefSeq 提 …