Toxic epidermal necrolysis-like acute cutaneous lupus erythematosus (TEN-like ACLE) is a rare manifestation of systemic lupus erythematosus (SLE) that mimics TEN clinically by the presence of widespread denudation and blistering; and histologically because …

2018年5月15日 · TEN-like ACLE, a rare manifestation of SLE that closely mimics TEN, can be distinguished by characteristic clinical and laboratory findings. A 27-year-old man with SLE who developed TEN-like ACLE after initiating mycophenolate mofetil for active SLE is reported.

TEN is classified under Acute cutaneous lupus erythematosus (ACLE) as per Gilliam and Sontheimer classification although it can be a feature of subacute cutaneous lupus erythematosus (SCLE) as well. Lupus-associated TEN was first suggested by Mandelcorn and Shear in 2003 as a novel manifestation of LE, resulting from acute necrosis of the ...

2024年4月1日 · TEN-like ACLE is a rare, hyperacute and life-threatening form of cutaneous lupus erythematosus seen in patients with SLE. These cutaneous lesions appear in a photo-distributive pattern as tense, vesiculobullous eruptions eventually causing extensive epidermal necrosis.

In the setting of LE, it is exigent to determine the trigger for severe TEN-like manifestations—whether it is drug induced or is a manifestation of acute cutaneous LE (ACLE). Herein, we report an interesting case of TEN-like LE, …

Current treatment options of TEN-like ACLE include intravenous IgG therapy and intravenous corticosteroids. Etanercept blocks TNFα receptor–induced pathways; an off-label use has recently been proposed for the treatment of autoimmune bullous diseases.

皮肤型红斑狼疮（cutaneous lupus erythematosus，CLE）的皮肤损伤分为两大类：特异性与非特异性。 前者有助于诊断CLE，后者则难以与多种临床疾病进行鉴别。 CLE分为三型：ACLE、SCLE、CCLE. 其中特异性CLE根据病程又分为急性皮肤型LE（Acute Cutaneous LE，ACLE）、亚急性皮肤型LE（Subacute Cutaneous LE，SCLE）和慢性皮肤型LE（Chronic Cutaneous LE，CCLE）。 一、ACLE. ACLE患者皮肤表现的临床特点： ①局灶或全身分布； ②“蝶形 …

TEN-like ACLE, a rare manifestation of SLE that closely mimics TEN, can be distinguished by characteristic clinical and laboratory findings. A 27-year-old man with SLE who developed TEN-like ACLE after initiating mycophenolate mofetil for active SLE is reported.

2021年3月4日 · Toxic epidermal necrolysis-like acute cutaneous lupus erythematosus (TEN-like ACLE) is a rare manifestation of systemic lupus erythematosus (SLE). Because of its rarity, little is known about this entity. In this report, we describe a case of two women previously diagnosed with SLE that presented TEN-like skin lesions.

2025年3月21日 · Acute cutaneous lupus erythematosus (ACLE) is the most common form of cutaneous lesions of lupus associated with systemic lupus erythematosus (SLE). It can...