Using rat ACL transection (ACLT) and ACLR models, we aimed to reveal (1) the formation process of meniscal tears secondary to ACLT and (2) the protective effects of ACLR on secondary meniscal tears. ACLT surgery alone or with ACLR was performed on the knees of rats.

To overcome this, we developed an animal model of ACLR-induced arthrofibrosis without immobilization. Materials and Methods: Thirteen male Wistar rats were divided into ACL transection (ACLT) and ACLR groups. Surgery was performed in the right knees and untreated left knees were used as controls.

2022年7月15日 · In this study, we first found that BMSC-Exos could regulate the polarization of macrophages to promote tendon-bone healing in rats after ACLR. The specific mechanism was that miR-23a-3p in BMSCs-Exos could inhibit IRF1 expression and the NF-κB signaling pathway in macrophages, promote the polarization of M1 macrophages to M2 macrophages and ...

2022年1月5日 · This study presents a cost-effective, new relevant and objective rat model associated with low morbidity for the preliminary study of bio-implantable materials designed for remnants-preserving ACL surgery after mid-substance ACL tear.

2015年3月2日 · In the rat model of ACLR, 3 mg/ml GHK-Cu induced greater cell infiltration into the graft mid-substance as compared to 0.3 mg/ml GHK-Cu, resulting in a corresponding decrease of collagen birefringence (Fig. 5). Cell repopulation of the tendon graft is essential for graft survival and remodeling.

Hypothesis: Doxy promotes graft healing and alleviates the progression of PTOA after ACLR. Study design: Controlled laboratory study. Methods: Sprague Dawley rats (n = 74; age, 12-13 weeks; male) that underwent ACLR were divided into untreated control and Doxy treatment (50 mg/kg/d orally until sacrifice) groups.

There is an essential demand for developing biocompatible grafts for knee anterior cruciate ligament reconstruction (ACLR). This study investigated cell infiltration into decellularized bovine tendon xenografts using a rat knee ACLR model. Twelve …

The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu(II) (GHK-Cu) is a well-known activator of tissue remodeling. We investigated whether GHK-Cu can improve graft healing following ACLR. 72 rats underwent unilateral ACLR were randomized to saline, 0.3mg/ml or …

2022年7月15日 · In this study, we observed in vivo and in vitro the effect of rat BMSC-Exos on tendon-bone healing after ACLR and its possible mechanism. Highly expressed miRNAs in rat BMSC-Exos were selected by bioinformatics and verified in vitro.

In the current study, we develop a novel rat model mimicking the clinical features of SA undergoing ACLR. This novel animal model could effectively mimic and characterize acute S. aureus infection after ACLR, which supports further study on infection prevention and treatment undergoing ACLR.