2024年12月24日 · ACMSD (Aminocarboxymuconate Semialdehyde Decarboxylase) is a Protein Coding gene. Diseases associated with ACMSD include Pellagra and Epilepsy. Among its related pathways are superpathway of tryptophan utilization and Kynurenine pathway and links to …

2024年11月1日 · ACMSD (α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase) is a key metalloenzyme critical for regulating de novo endogenous NAD + /NADH biosynthesis through the tryptophan-kynurenine pathway. This decarboxylase is a recognized target implicated in mitochondrial diseases and neurodegenerative disorders.

In this study, we aimed to investigate the therapeutic implications of ACMSD inhibition in the treatment of metabolic dysfunction-associated steatotic liver disease/steatohepatitis (MASLD/MASH).

2019年4月1日 · ACMSD converts ACMS into aminomuconic semialdehyde (AMS) in a de novo NAD + biosynthetic pathway. Increasing ACMSD expression shifts the balance from de novo NAD + biosynthesis toward acetyl-CoA production, leading to the development of niacin dependency.

高度保守的α-氨基-β-羧基粘康酸-ε-半醛脱羧酶（ACMSD）是调节色氨酸从头合成NAD + 的关键酶。 糖尿病心肌病 (DCM) 中的 NAD + 代谢尚未阐明。 将小鼠分为非糖尿病（NDM）组、链脲佐菌素（STZ）诱导的糖尿病（DM）组和烟酰胺（NAM）治疗（DM + NAM）组。 在小鼠和糖尿病患者中研究了 ACMSD 介导的 NAD + 代谢。 DM小鼠心脏中的NAD + 水平显着低于NDM组。 补充NAM可以通过挽救途径增加NAD + 水平，部分增加心肌毛细血管密度并改善心肌纤维化。 …

2019年2月21日 · ACMSD converts ACMS into aminomuconic semialdehyde (AMS) in a de novo NAD+ biosynthetic pathway. Increasing ACMSD expression shifts the balance from de novo NAD+ biosynthesis toward acetyl-CoA production, leading to the development of …

2020年8月6日 · Phthalate esters enhance quinolinate production by inhibiting alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD), a key enzyme of the tryptophan pathway. Fukuwatari T, et al. Toxicol Sci, 2004 Oct. PMID 15229365.

A recent study (Palzer et al., Cell Rep. 2018, 25;1359-1370) demonstrated that alpha-amino-beta-carboxy-muconate-semialdehyde decarboxylase (ACMSD) is a key regulator of NAD⁺ metabolism and overexpression of human …

ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS. [supplied by OMIM, Oct 2004]

2024年6月17日 · ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS. [supplied by OMIM, Oct 2004] An atlas of genetic influences on human blood metabolites.