2024年12月24日 · ACOD1 (Aconitate Decarboxylase 1) is a Protein Coding gene. Diseases associated with ACOD1 include Epiphyseal Dysplasia, Multiple, 4 and Aortic Aneurysm. Among its related pathways is Glucose / Energy Metabolism.

免疫应答基因 1 ( Irg1 ) 编码的 顺乌头酸脱羧酶 (ACOD1)作为负责巨噬细胞中TCA循环中间体顺乌头酸脱羧的酶，LPS激活巨噬细胞后，ACOD1增加，顺式乌头酸从TCA循环中转移，重新调整其用途以产生衣康酸。 目前的研究表明，衣康酸是一种重要的免疫代谢产物，对免疫、宿主防御和肿瘤发生具有深远的影响。 在结构上， 衣康酸酯 是一种五碳二羧酸，带有一个 α,β-不饱和烯烃。 它在结构和化学上与磷酸烯醇丙酮酸、琥珀酸、丙二酸和富马酸等其他代谢物相似。 这种相似性 …

2023年10月14日 · Acod1敲除可促进适应性免疫并增强免疫疗法. Acod1 消减的转移抑制作用取决于适应性免疫，因为 Rag1-/- Acod1+/+ 和 Rag1-/- Acod1-/- 小鼠表现出相似的 E0771-TR 肺转移负荷和存活时间（图 7A-7C）。

2020年6月29日 · Functionally, ACOD1 mediates itaconate production, oxidative stress, and antigen processing and plays dual roles in immunity and diseases. On the one hand, activation of the ACOD1 pathway may...

Immunometabolism plays a fundamental role in health and diseases and involves multiple genes and signals. Aconitate decarboxylase 1 (ACOD1; also known as IRG1) is emerging as a regulator of immunometabolism in inflammation and infection. Upregulation of ACOD1 expression occurs in activated immune ce …

Sepsis is a challenging clinical syndrome caused by a dysregulated host response to infection. Here, we identified an unexpected proseptic activity of aconitate decarboxylase 1 (ACOD1) in monocytes and macrophages. Previous studies have suggested that ACOD1, also known as immune-responsive gene 1, is an immunometabolic regulator that favors ...

线粒体代谢酶 ACOD1（Aconitate decarboxylase 1；又称IRG1）在巨噬细胞激活后迅速被诱导表达，催化顺乌头酸脱羧和产生高浓度衣康酸 （Itaconate,ITA）。 Irg1 基因敲除小鼠的遗传研究表明，衣康酸抑制炎症基因表达和发挥抗炎作用。

Enables aconitate decarboxylase activity. Involved in defense response; positive regulation of antimicrobial humoral response; and tolerance induction to lipopolysaccharide. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

乌头酸脱羧酶 1（acod1，也称为免疫反应基因 1）是一种负责催化衣康酸产生的线粒体酶，最初被鉴定为细菌 lps 诱导基因，参与小鼠巨噬细胞的先天免疫。

2024年12月11日 · acod1基因的表达主要在免疫系统细胞中，尤其是在巨噬细胞受到病原体刺激后显著上调。 它的表达受到多种转录因子的调控，包括NF-κB、IRF3和STAT1等，这些因子在免疫反应中起到关键作用。