Redox Biol 综述︱吕欣等评述衣康酸在炎症和氧化应激性疾病中的 …
小鼠的原代骨髓来源巨噬细胞（BMDM）在激活期间，促炎细胞因子生成增加，而IRG1编码的顺式乌头酸脱羧酶1（ACOD1）可以催化TCA循环的中间产物顺式乌头酸发生脱羧反应，生成中间 …
衣康酸:巨噬细胞功能代谢重编的典型产物 - 知乎
根据衣康酸衍生物或Irg1缺陷巨噬细胞的证据，已经确定了衣康酸的几个靶点，包括琥珀酸脱氢酶（SDH），它们可以阻止琥珀酸氧化为富马酸，并减少mtROS的产生。
Citraconate inhibits ACOD1 (IRG1) catalysis, reduces ... - Nature
2022年6月2日 · Only citraconate inhibits catalysis of itaconate by cis -aconitate decarboxylase (ACOD1), probably by competitive binding to the substrate-binding site. These results reveal …
ACOD1 in immunometabolism and disease - Nature
2020年6月29日 · Functionally, ACOD1 mediates itaconate production, oxidative stress, and antigen processing and plays dual roles in immunity and diseases. On the one hand, activation …
衣康酸:巨噬细胞功能代谢重编的典型产物 - ChemicalBook
2020年10月26日 · 通过琥珀酸脱氢合酶（sdh）进行的琥珀酸氧化可以在复合物i处进行反向电子输运，从而驱动活性氧物质（ros）的生成以促进缺氧诱导因子1α(hif1α)和il-1β的生成[8]。
The Dual Role of ACOD1 in Inflammation
2023年8月15日 · Anti-inflammatory effect of ACOD1. ACOD1-mediated itaconate production inhibits SDH activity, leading to succinate accumulation. Excess succinate suppresses the …
eLife丨内源性衣康酸不发挥抗炎抗氧化应急作用，外源性衣康酸发 …
RNA-sequencing demonstrated Acod1 (Aconitate decarboxylase 1) as one of the top genes induced by PM in macrophages. Acod1 encodes a mitochondrial enzyme that produces …
Mitochondrial ACOD1/IRG1 in infection and sterile inflammation
ACOD1-mediated itaconate production impairs SDH activity, decreases succinate oxidation, and promotes succinate accumulation, thereby suppressing the inflammatory processes mediated …
Acod1-mediated inhibition of aerobic glycolysis suppresses …
2024年12月1日 · The lack of itaconate in the absence of Acod1 results in overactivation of Sdh, leading to repurposing of the electron transport chain for ROS production and is associated …
The Dual Role of ACOD1 in Inflammation - Oxford Academic
2023年8月15日 · Anti-inflammatory effect of ACOD1. ACOD1-mediated itaconate production inhibits SDH activity, leading to succinate accumulation. Excess succinate suppresses the …