2024年12月24日 · ACSL5 (Acyl-CoA Synthetase Long Chain Family Member 5) is a Protein Coding gene. Diseases associated with ACSL5 include Diarrhea 13 and Diarrhea. Among its related pathways are Fatty acid metabolism and arachidonate biosynthesis III (metazoa). Gene Ontology (GO) annotations related to this gene include long-chain fatty acid-CoA ligase activity.

Long-chain-fatty-acid—CoA ligase 5 is an enzyme that in humans is encoded by the ACSL5 gene. [5] [6] The protein encoded by this gene is an isozyme of the long-chain-fatty-acid-CoA ligase family.

2023年2月1日 · A fatty acid must be converted to fatty acyl-CoA to oxidize or be incorporated into new lipids. Acyl-CoA synthetase long-chain family member 5 (ACSL5) is localized in the endoplasmic reticulum and mitochondrial outer membrane, where it catalyzes the formation of fatty acyl-CoAs from long-chain fatty acids (C16–C20).

Acyl-CoA synthetase long-chain family member 5 (ACSL5) is localized in the endoplasmic reticulum and mitochondrial outer membrane, where it catalyzes the formation of fatty acyl-CoAs from long-chain fatty acids (C16–C20). Fatty acyl-CoAs are then used in lipid synthesis or β-oxidation mediated pathways.

Acyl-CoA synthetase long-chain family member 5 (ACSL5) is localized in the endoplasmic reticulum and mitochondrial outer membrane, where it catalyzes the formation of fatty acyl-CoAs from long-chain fatty acids (C16–C20). Fatty acyl-CoAs are then used in lipid synthesis or β-oxidation mediated pathways.

摘要： 长链脂酰辅酶 A 合成酶系 (acyl-CoA synthetase long chain family, ACSLs) 催化辅酶 A (CoA) 与 12 ~ 20 个碳链长度的长链脂肪酸连接, 参与脂质的合成和代谢过程。 ACSL5 是唯一一种既位于线粒体上又 参与肠上皮细胞凋亡的 ACSLs 亚型, 在多种组织中都有表达。 已有许多关于不同癌症的研究报道 ACSL5 在 其中的表达明显不同于健康个体, 且 ACSL5 高表达对肺癌、 胰腺癌、 乳腺癌和卵巢癌患者的预后有积极影 响。 通过研究 ACSL5 参与的脂质代谢在癌症中的作 …

2025年2月8日 · ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/beta-catenin signaling by palmitoylation modification. More than just a histone deacetylase: cytoplasmic SIRT6 facilitates fatty acid oxidation through ACSL5 deacetylation.

ACSL5是唯一一种既位于线粒体上又ACSLs 亚型, 在多种组织中都有表达。 已有许多关于不同癌症的研究报道ACSL5在, 且ACSL5 高表达对肺癌、 胰腺癌、乳腺癌和卵巢癌患者的预后有积极影参与的脂质代谢在癌症中的作用,为靶向脂质代谢酶的癌症治疗提供新的靶点和策略。 【Abstract】 Acyl-CoA synthetase long chain family (ACSLs) catalyzes the connection of CoA with 12-20 long chain fatty acids and participates in lipid synthesis and metabolism.

该基因编码的蛋白质是长链脂肪酸辅酶 A 连接酶家族的一种同工酶。 尽管底物特异性、亚细胞定位和组织分布不同，但该家族的所有同工酶都将游离的长链脂肪酸转化为脂肪酰基辅酶 A 酯，从而在脂质生物合成和脂肪酸降解中发挥关键作用。 这种同功酶在子宫和脾脏中高度表达，在正常大脑中有微量表达，但在恶性神经胶质瘤中水平显着升高。 该基因在介导脂肪酸诱导的神经胶质瘤细胞生长中发挥作用。 已发现该基因编码两种不同亚型的三种转录变体。 [RefSeq 提供，2008 年 …

2021年10月15日 · ACSL5 is nuclear-coded and expressed in the mitochondria and physiologically participates in the pro-apoptotic sensing of cells. ACSL5 is widely expressed in the intestinal tissues, where it sensitizes enterocytes to pro-apoptotic signals by inducing expression of mitochondrial mortalin (HSPA9) (Klaus et al., 2014a). ACSL5 induces the synthesis ...