2024年12月24日 · ACSL6 (Acyl-CoA Synthetase Long Chain Family Member 6) is a Protein Coding gene. Diseases associated with ACSL6 include Myelodysplastic Syndrome and Leukemia. Among its related pathways are Fatty acid metabolism and …

Acyl-CoA synthetase long-chain family member 6 is an enzyme that in humans is encoded by the ACSL6 gene. [5][6][7] Long-chain acyl-CoA synthetases such as ACSL6, catalyze the formation of acyl-CoA from fatty acids, ATP, and CoA. [6] The ACSL6 gene is located on the 5th chromosome, with its specific location being 5q31.1.

2021年10月15日 · ACSL6 downregulation has been observed in many forms of cancers, except in colorectal cancer (CRC). Here, we address the differential regulatory mechanisms of the ACSL family members as well as their functions in carcinogenesis.

2024年9月18日 · Here, we report that long-chain acyl-CoA synthase 6 (ACSL6) is highly expressed in liver cancer and correlated with poor prognosis. ACSL6 promotes tumor growth, metastasis, and immune evasion mediated by IL-18, independent of its metabolic enzyme activity.

2025年2月8日 · ACSL6 drives acyl-CoA toward lipid synthesis and its downregulation improves mitochondrial biogenesis, respiratory capacity and lipid oxidation; variations in the ACSL6 gene may contribute to the quantity of cigarettes smoked; Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

2021年10月15日 · ACSL6 downregulation has been observed in many forms of cancers, except in colorectal cancer (CRC). Here, we address the differential regulatory mechanisms of the ACSL family members as well as their functions in carcinogenesis.

2024年9月18日 · Here, we report that long-chain acyl-CoA synthase 6 (ACSL6) is highly expressed in liver cancer and correlated with poor prognosis. ACSL6 promotes tumor growth, metastasis, and immune evasion mediated by IL-18, independent of its metabolic enzyme activity.

2024年8月21日 · Acyl-CoA synthetase 6 (Acsl6)-facilitated enrichment of docosahexaenoic acid (DHA) in the retina is essential for rod photoreceptor function, viability and control of basal activity of the...

2025年2月8日 · ACSL6 is essential for germ cell DHA enrichment and is required for normal spermatogenesis and male fertility. Acsl6 knockout mice demonstrate motor impairments, altered glutamate metabolism, and increased astrogliosis and microglia activation.

2010年4月29日 · Human long-chain acyl-CoA synthetase member 6, ASCL6, is a form present in the plasma membrane of cells. Splicing events affecting the amino-terminus and alternative motifs near the ATP-binding site generate different isoforms of ACSL6.