2024年12月24日 · ACSS2 (Acyl-CoA Synthetase Short Chain Family Member 2) is a Protein Coding gene. Diseases associated with ACSS2 include Orofacial Cleft 1 and Myasthenic Syndrome, Congenital, 10. Among its related pathways are ethanol degradation II and Transcriptional activation of mitochondrial biogenesis.

acss2是哺乳动物细胞中首次被发现的乳酰-coa合成酶! 尽管 组蛋白乳酰化 修饰已经得到了广泛的研究，但是其中细节仍不清晰。 比如，是谁催化乳酸生成乳酰辅酶A（乳酰-CoA），又是谁将乳酰-CoA的酰基转移到目标蛋白上完成乳酰化，完成该过程的酶在众多的研究 ...

Acyl-coenzyme A synthetase short-chain family member 2 is an enzyme that in humans is encoded by the ACSS2 gene. [5][6] This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl - CoA from acetate in a reaction that requires ATP.

乙酰辅酶 A 合成酶 2 (ACSS2) 是乙酰辅酶 A 合成酶 (ACSS) 家族的重要成员，可催化乙酸转化为乙酰辅酶 A (乙酰辅酶 A)。 目前，乙酰辅酶A被认为是能量底物代谢中的重要中间代谢物。 此外，营养物质通过乙酰辅酶A 汇聚到共同的代谢途径、三羧酸循环和氧化磷酸化中。 ACSS2 不仅在物质能量代谢中起着至关重要的作用，它还参与各种乙酰化过程的调节，如组蛋白和转录因子乙酰化的调节。 ACSS2 介导的乙酰化调节与物质代谢和肿瘤发生有关。 在哺乳动物细胞 …

2025年2月4日 · In this study, we demonstrated that activation of epidermal growth factor receptor (EGFR) induced translocation of acetyl-CoA synthetase 2 (ACSS2) into the nucleus, where ACSS2 acted as a lactyl-CoA synthetase to produce lactyl-CoA and forms a complex with lysine acetyltransferase 2A (KAT2A).

2022年7月7日 · ACSS2 catalyzes the production of AMP, which in turn signals a decline in cellular energy reserves. ACSS2 drives protein acetylation and AMPK activation by converting acetate and ATP into acetyl-CoA and AMP. After phosphorylation by AMPK, ACSS2 promotes the formation of acetyl-CoA while reducing the ATP level and increasing the AMP level (Fig. 4).

2025年2月4日 · A combination treatment with an ACSS2-KAT2A interaction-blocking peptide and an anti-PD-1 antibody induces an additive tumor-inhibitory effect. These findings uncover ACSS2 and KAT2A as hitherto unidentified lactyl-CoA synthetase and lactyltransferase, respectively, and the significance of the ACSS2-KAT2A coupling in gene expression and tumor ...

2024年2月8日 · Mechanistically, ACSS2 binds directly acetylated PPARγ in the presence of ligand and recruits SIRT1 and PRDM16 to activate UCP1 expression. In turn, SIRT1 triggers ACSS2 translocation from...

2025年2月25日 · Elevated incidence of metabolic disorders has been reported worldwide in the recent decade, highlighting the need for developing efficient therapies. These diseases result from a complex interplay of various factors that contribute to disease progression, complications, and resistance to current treatment options. Acetyl-CoA Synthetase Short Chain Family Member 2 (ACSS2) is a nucleo-cytosolic ...

acss2通过组蛋白乙酰化（h3k9，h4k12）介导的谷氨酸受体亚基的表达进而调控兴奋性突触传递，该作用不仅对维持正常空间记忆能力至关重要，也参与了ad鼠的空间记忆能力的受损；更为重要的是，研究者发现补充acss2底物——乙酸盐上调5×fad小鼠的组蛋白乙酰化 ...