α-辅肌动蛋白1 （英语：ACTN1） 是 骨骼肌 细胞中 肌动蛋白 附着于 Z线 所必须的 [1]，也是其在 平滑肌 中附于电子致密部分所需。 起功能的辅肌动蛋白是反向平行的 二聚体，在 肌节 的细肌丝之间交叉链接。 非肌节特异性的α-辅肌动蛋白（ACTN1和ACTN4）在组织中广泛表达，棒状的α-辅肌动蛋白二聚体的两个末端都包含有肌动蛋白结合结构域。 ACTN4上的突变可造成肾脏疾病 局灶性节段性肾小球硬化症。 ^ Ganong's Review of Medical Physiology, 24th Edition. Lange …

Actinin is a microfilament protein. The functional protein is an anti-parallel dimer, which cross-links the thin filaments in adjacent sarcomeres, and therefore coordinates contractions between sarcomeres in the horizontal axis. Alpha-actinin is a part of the spectrin superfamily.

The alpha actinin (ACTN) family proteins are actin-bundling proteins that are evolutionarily conserved and possess several functional domains. Vertebrates including humans express four unique actinin genes that display distinct expression patterns and biochemical properties.

Actin大致可分为六种，其中四种是不同肌肉组织特异性的，包括α-skeletal muscle actin，α-cardiac muscle actin，α-smooth muscle actin，和γ-smooth muscle actin；其余两种广泛分布于各种组织中，包括β-actin (β-non-muscle)和γ-non-muscle actin。 不同的actin之间同源性大于90%，但在N-terminal同源性仅50--60%，因此N-terminal常被用作actin的抗原。 β-actin的蛋白水平通常不会发生改变，因此被广泛用于Western时上样量是否一致的参照。 也常被用于免疫染色 …

Alpha-actinin (α-actinin) is a ubiquitous cytoskeletal protein, which belongs to the superfamily of filamentous actin (F-actin) crosslinking proteins. It is present in multiple subcellular regions of both muscle and non-muscle cells, including cell-cell and cell-matrix contact sites, cellular protru …

肌动蛋白 （英語： Actin）是一类 分子量 大约在42,000的 球状蛋白质。 除了已经知道的 线虫 类精子细胞之外，在所有的 真核细胞 当中均发现有该蛋白质，浓度约在100μM以上，其质量约为42 kDa，直径为4至7nm。 肌动蛋白是生物体中 微丝 的两个 单体 亚基 之一，而微丝则是 细胞骨架 三大组成结构之一，肌动蛋白还构成了 肌细胞 中具有收缩功能的组织。 所以，肌动蛋白对于细胞活动起到很大的作用，比如 肌肉 的收缩，细胞的转移、 分裂 和原质的流动、 囊泡 和 胞器 …

2008年5月19日 · Alpha-actinin is a cytoskeletal actin-binding protein and a member of the spectrin superfamily, which comprises spectrin, dystrophin and their homologues and isoforms. It forms an anti-parallel rod-shaped dimer with one actin-binding domain at each end of the rod and bundles actin filaments in multiple cell-type and cytoskeleton frameworks.

Alpha-actinin is a cytoskeletal actin-binding protein and a member of the spectrin superfamily, which comprises spectrin, dystrophin and their homologues and isoforms. It forms an anti-parallel rod-shaped dimer with one actin-binding domain at each end of the rod and bundles actin filaments in multi …

Alpha-actinin is a cytoskeletal actin-binding protein and a member of the spectrin superfamily, which comprises spectrin, dystrophin and their homologues and isoforms. It forms an anti-parallel rod-shaped dimer with one actin-binding domain at each end of the rod and bundles actin filaments in multiple cell-type and cytoskeleton frameworks.

Actinins are one of the major actin cross-linking proteins found in virtually all cell types and are the ancestral proteins of a larger family that includes spectrin, dystrophin and utrophin. Invertebrates have a single actinin-encoding ACTN gene, while mammals have four.