2020年9月29日 · Results: Treatment with ACTD was shown to significantly reduce tumor growth in 2 recurrent GBM patient-derived models and significantly increased survival. ACTD is also …

Interestingly, we show that actinomycin D specifically targets and down-regulates the expression of the stem cell transcription factor, Sox-2. Additionally, down-regulation of Sox-2 leads to …

Solution structure of the HMG box DNA-binding domain of human stem cell transcription factor SOX2. Actinomycin D (arrow) docks to a hydrophilic (blue) region of the HMG major wing. …

Here, we demonstrate how high-throughput screening (HTS) in multicellular spheroids can generate physiologically relevant patient chemosensitivity data using patient-derived cells in a …

See "Actinomycin D downregulates Sox2 and improves survival in preclinical models of recurrent glioblastoma" on page 1289. See the article by Taylor et al., pp. 1289–1301, in this issue . In …

2020年7月17日 · Identification of a SOX2-dependent subset of tumor- and sphere-forming glioblastoma cells with a distinct tyrosine kinase inhibitor sensitivity profile.

Downregulation of SOX-2, a stem cell transcription factor, was investigated via western blot in cell lysates and through immunohistological assessment of murine brain tissue. Tumour growth in …

确定放线菌素 d (actd) 在一组 12 个患者来源的神经胶质瘤干细胞 (gsc) 系中具有细胞毒性。 1,2 actd 治疗显着降低了 2 个复发性胶质母细胞瘤 (gbm) 患者衍生模型中的肿瘤生长，并显着提高 …

1. High-throughput chemosensitivity data demonstrated the broad efficacy of actinomycin D, which was validated in 3 preclinical models of glioblastoma. 2. Actinomycin D downregulated …

2020年3月30日 · Downregulation of Sox2, a stem-cell transcription factor, was investigated via western blot and through immunohistological assessment of murine brain tissue. Results: …