2024年12月24日 · ACVR1B (Activin A Receptor Type 1B) is a Protein Coding gene. Diseases associated with ACVR1B include Pancreatic Cancer and Transposition Of The Great Arteries, …

激活素是二聚体生长和分化因子，属于结构相关信号转导蛋白的转化生长因子-β (TGF-β) 超家族。 激活素通过受体丝氨酸激酶的异聚复合体发出信号，其中至少包括两种 I 型和两种 II 型受体。 …

Activin receptor type-1B is a protein that in humans is encoded by the ACVR1B gene. [5] [6] ACVR1B or ALK-4 acts as a transducer of activin or activin-like ligands (e.g., inhibin) signals. …

1B型激活素受体（Activin receptor type-1B），缩写为ACVR1B或ALK-4，在人体中是一种由ACVR1B基因 编码的蛋白质 [5] [6] 。 ALK-4能够对 激活素 或激活素样配体（即 抑制素 ）的 …

2025年2月8日 · Title: Implication of rare genetic variants of NODAL and ACVR1B in congenital heart disease patients from Indian population. Activin A increases human trophoblast invasion …

2025年2月8日 · Data suggest that activin A up-regulates SNAIL expression via ALK4/ACVR1B-induced SMAD signaling in trophoblast cells; elevated SNAIL contributes to up-regulation of …

该基因编码的蛋白可启动激活素结合活性和蛋白丝氨酸/苏氨酸激酶活性。 参与肽基-苏氨酸磷酸化。 作用于多个过程的上游或内部，包括激活素受体信号通路；毛囊发育；和基因表达的调控 …

2024年4月1日 · Activated ACVR1B or ACVR1C subsequently phosphorylates SMAD2/3, which then forms a complex with SMAD4, and the complex translocate into the nucleus where it …

The ACVR1B gene encodes an activin A type IB receptor (location: 12q13.13). Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta …

2025年2月8日 · Enables activin binding activity and protein serine/threonine kinase activity. Involved in peptidyl-threonine phosphorylation. Acts upstream of or within several processes, …