2018年9月28日 · In this Review, we focus on a receptor known as triggering receptor expressed on myeloid cells 2 (TREM2), which promotes the optimal microglial function required to attenuate AD progression and...

2023年1月12日 · Here we describe a high-affinity human TREM2-activating antibody engineered with a monovalent transferrin receptor (TfR) binding site, termed antibody transport vehicle (ATV), to facilitate...

2023年2月3日 · Denali Therapeutics和武田公司开发了一种能够激活TREM2受体的抗体DNL919（ATV：TREM2），通过静脉注射给药，有望改善TREM2这一关键大脑免疫基因的功能。 好事多磨。

2020年11月14日 · 在这些小胶质细胞相关的AD风险位点中，髓样细胞表达触发受体2（TREM2）基因上的变异对疾病风险影响最大，与单个APOE ε4等位基因产生的风险相似。 在中枢神经系统，TREM2主要在小胶质细胞中表达，在小胶质细胞相关的神经退行性疾病中发挥着重要作用。 TREM2作为免疫球蛋白超家族中的一种，是细胞膜上的小胶质细胞的关键感受器，介导对磷脂、APOE和其他刺激的反应。 TREM2通过激活其配体，也就是酪氨酸激酶结合蛋 …

2022年6月3日 · Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane immune receptor that is mainly expressed on microglia in the brain and macrophages in the periphery. Recent studies have identified TREM2 as a risk factor for Alzheimer's disease (AD). Increasing evidence has sho …

2025年3月6日 · Rare TREM2 variants are strong risk factors for Alzheimer’s disease (AD) [1,2,3,4,5,6].The triggering receptor expressed on myeloid cell 2 (TREM2) gene is situated on chromosome 6, it encodes a transmembrane protein of 230 amino acids, and it is expressed exclusively in microglia within the brain [].The TREM2 protein appears to be important in microglial function and AD development [8,9,10 ...

2022年6月3日 · Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane immune receptor that is mainly expressed on microglia in the brain and macrophages in the periphery. Recent studies have identified TREM2 as a risk factor for Alzheimer’s disease (AD).

2024年3月1日 · Triggering receptor expressed on myeloid cells 2 (TREM2) is a membrane glycoprotein that plays a crucial role in the regulation of microglial survival, activation, phagocytosis, as well as in the maintenance of brain homeostasis and the inflammatory response to injury or neurodegeneration.

2023年9月1日 · In this review, we summarize our understanding of TREM2 biology, explore the function of TREM2 and its multiple mechanisms in microglia, highlight the role of TREM2 and microglia in AD, and whether the modulation of this protein can be used to develop new therapeutic approaches for AD.

trem2 r47h和r62h 两个变异体会增加个体晚发性ad 风险，该发现使trem2 成为ad 领域一个新的 研究热点。 本文主要围绕小胶质细胞TREM2 的结构、表达调控、信号转导、功能及其在AD 中的病理学