Adenosine deaminase (also known as adenosine aminohydrolase, or ADA) is an enzyme (EC 3.5.4.4) involved in purine metabolism. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues. Its primary function in humans is the development and maintenance of the immune system. [5]

Pleural fluid adenosine deaminase (ADA) is a useful diagnostic test for tuberculous pleural effusion (TPE), but its exact threshold and accuracy in clinical decision-making is unclear. We aimed to assess diagnostic performance of ADA in TPE and …

Adenosine deaminase test is a common biochemical test to determine Adenosine Deaminase (ADA) enzyme levels present in body fluids, including sputum, cerebrospinal fluids, pleural fluids, synovial fluids, ascites, and blood serum.

2021年1月5日 · The adenosine deaminase (ADA) test is not a diagnostic test, but it may be used along with other tests such as pleural fluid analysis, acid-fast bacillus (AFB) smear and culture, and/or tuberculosis molecular testing to help determine whether a person has a Mycobacterium tuberculosis infection (tuberculosis or TB) of the lining of the lungs ...

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2023年2月19日 · ADA (Adenosine Deaminase) Test is based on the enzymatic deamination of adenosine to inosine which is converted to hypoxanthine by purine nucleoside phosphorylase (PNP). Hypoxanthine is then converted to uric acid and …

This study showed that serum ADA with high specificity percentage might be a useful alternative test to rule out diagnosis of PTB. Serum ADA activity can be used in the differentiation of non-TB cases from TB cases as a supplementary laboratory test in patients strongly suspected to have negative PTB smear test results.

Adenosine Deaminase, Pleural Fluid - An elevated level of adenosine deaminase (AD) in human serum, plasma or select body fluids is used as a surrogate marker for inflammation or infectious disease. In CSF, pleural effusions, and pericardial fluid in particular, elevated AD activity has been shown to be associated with tubercular lesions.

2023年5月2日 · The ADA test, also known as the adenosine deaminase test, is typically recommended by physicians to diagnose or rule out the presence of Mycobacterium tuberculosis in patients. The test is designed to identify tuberculosis in the pleural fluid and aid in its diagnosis.

2023年9月9日 · One common method used for ADA testing is the Giusti-Sundman method, which measures the enzymatic activity of ADA by assessing its ability to convert adenosine to inosine. Other methods, such as colorimetric assays or fluorometric assays, may also be …