2023年11月12日 · The mechanism of action of adalimumab involves the inhibition of the binding of TNF-α to its receptor, affecting both the soluble and membrane-bound forms. Specifically, adalimumab inhibits the interaction of TNF-α to the cell surface TNF receptors, p55 (TNFR1) and p75 (TNFR2), thereby disrupting cytokine-driven inflammatory processes.

Mechanism of action. Adalimumab binds with specificity to tumor necrosis factor-alpha (TNF-alpha) and inhibits its interaction with the p55 and p75 cell surface TNF receptors.

The mechanism of action of adalimumab is primarily linked to the neutralization of TNF-alpha bioactivity by preventing the interaction of TNF-alpha with the cell surface TNF receptors.

2020年2月17日 · Mechanism of Action. Adalimumab is a recombinant monoclonal antibody that binds to human tumor necrosis factor alpha (TNF-alpha), thereby interfering with binding to TNFα receptor sites and subsequent cytokine-driven inflammatory processes.

2023年11月12日 · This activity comprehensively reviews the indications, mechanism of action, administration, potential adverse effects, and contraindications of adalimumab, providing the interprofessional healthcare team with the necessary information to effectively utilize the drug and treat certain autoimmune conditions.

The main mechanism of action for ADA is that of binding to TNFα and thereby blocking the interaction of TNFα with the p55 and p75 cell surface TNF receptors. ADA binds to both soluble and cell-bound TNFα.

Adalimumab (Humira) is a fully humanized monoclonal antibody that binds directly to TNF-α with a result that both type 1 and type 2 TNF-α receptors are blocked. Adalimumab has a half-life of about 2 weeks following its usual subcutaneous administration.

12.1 Mechanism of Action. Adalimumab products bind specifically to TNF-alpha and block its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab products also lyse surface TNF expressing cells in vitro in the presence of complement. Adalimumab products do not bind or inactivate lymphotoxin (TNF-beta).