2024年8月27日 · Sinigaglia et al. demonstrate that Pkr is aberrantly activated in Adar mutant mice. ADAR1 protein inhibition of PKR activation requires a predicted direct protein interaction …

2015年7月23日 · We propose that hyperediting of self-dsRNA by ADAR1 (such as the 3′UTRs of Klf1, Optn, and Oip5) generates multiple I-U mismatches that act to prevent MDA5 …

2022年8月4日 · 针对这个问题，作者对17类炎症性疾病和edQTL展开了共定位（colocalization）分析，精确地鉴定了194个与炎症性疾病有高度因果效应的双链RNA，命名为免疫原性双 …

2016年4月11日 · These structures, together with structure-guided mutagenesis and RNA-modification experiments, explain the basis of the ADAR deaminase domain's dsRNA …

2024年7月18日 · Adenosine deaminase acting on RNA 1 (ADAR1) converts adenosine to inosine in double-stranded RNA (dsRNA) molecules, a process known as A-to-I editing. ADAR1 …

Adenosine deaminase acting on RNA (ADAR) catalyzes the posttranscriptional conversion of adenosine to inosine in double-stranded RNA (dsRNA), which can lead to the creation of …

2015年3月9日 · Adenosine deaminases acting on RNA (ADARs) are the primary factors underlying adenosine to inosine (A-to-I) editing in metazoans. Here we report the first global …

2018年2月8日 · Mutations in ADAR1, an adenosine-to-inosine editing enzyme of dsRNA, cause Aicardi-Goutières syndrome, an autoinflammatory disorder associated with spontaneous …

2025年3月13日 · ADAR1-mediated RNA editing is a key regulator of the physiological dsRNA response, which prevents the cytoplasmic RNA sensors of the innate immune system from …

2025年3月13日 · As with a virus-infected cell, this dsRNA has the potential to be sensed by MDA5 and induce a type I IFN response, contributing to lenalidomide-induced cell death. However, in …