Adducin is a ubiquitously expressed membrane-skeletal protein localized at spectrin-actin junctions that binds calmodulin and is an in vivo substrate for protein kinase C (PKC) and Rho-associated kinase. Adducin is a tetramer comprised of …

Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure.

Adducin是新近发现的一种细胞膜骨架蛋白，它含有多个功能位点，参与细胞膜骨架网状结构的构建、细胞信号转导和细胞膜离子转运等，并有证据表明adducin与高血压的发病有着密切的联系。

2024年12月24日 · ADD1 (Adducin 1) is a Protein Coding gene. Diseases associated with ADD1 include Hypertension, Essential and Tracheoesophageal Fistula With Or Without Esophageal Atresia. Among its related pathways are Activation of cAMP-Dependent PKA and Unfolded Protein Response (UPR).

2018年5月16日 · This paper begins with a discussion on how adducin partakes in the structural formation of membrane skeleton, its regulation, and related functional characteristics, followed by a review on the pathogenesis of hypertension, biliary atresia, and cancer with respect to increased disease susceptibility mediated by adducin polymorphism and/or ...

ADD1 (adducin-1) is an actin-binding protein that has been shown to play important roles in the stabilization of the membrane cortical cytoskeleton and cell–cell adhesions. In this study, we show that ADD1 associates with mitotic spindles and is crucial for …

内收蛋白（adducin） 一种细胞膜骨架蛋白，可与钙调蛋白结合, 是由两个亚基组成的二聚体，每个红细胞约有30，000个分子。 它的形态似不规则的盘状物，高5.4nm，直径12.4nm.内收蛋白可与肌动蛋白及血影蛋白复合体结合，并且通过Ca2+和钙调蛋白的作用影响骨架 ...

Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit.

Adducin is a heteromeric protein with subunits containing a COOH-terminal myristoylated alanine-rich C kinase substrate (MARCKS)-related domain that caps and preferentially recruits spectrin to the fast-growing ends of actin filaments.

2018年5月16日 · Although adducin functions primarily as a membrane cytoskeletal protein, it is also an essential molecule in maintaining a wide range of physiological functions. Aberrant alterations of adducin resulting from genetic, transcriptional, epigenetic, and posttranslational modifications could be fatal.