Cell adhesion molecules (CAMs) are a subset of cell surface proteins [1] that are involved in the binding of cells with other cells or with the extracellular matrix (ECM), in a process called cell adhesion. [2] In essence, CAMs help cells stick to each other and to their surroundings.

细胞黏附分子 （英語： Cell adhesion molecules，缩写：CAMs）是位于细胞表面上的蛋白， [1] 参与了与其他细胞或 细胞外基质 （ECM）中的称为 细胞黏附 的 结合 （英语：Molecular binding） 過程。

Adhesion proteins exhibit precisely coded and conserved binding affinities and specificities that differ from one family member to another despite, in many cases, nearly identical sequences and structures. In numerous cases, clear relationships between the evolutionary design of adhesion protein families and biological function have become evident.

Cell adhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface.

We describe structures of select adhesion receptor complexes and their assembly into larger intercellular junction structures and discuss emerging principles that relate cell-cell organi-zation to the binding specificities and energetics of adhesion receptors.

2020年4月30日 · We describe structures of select adhesion receptor complexes and their assembly into larger intercellular junction structures and discuss emerging principles that relate cell-cell organization to the binding specificities and energetics of adhesion receptors.

The functional units of cell adhesion are typically multiprotein complexes made up of three general classes of proteins; the cell adhesion molecules/adhesion receptors, the extracellular matrix (ECM) proteins, and the cytoplasmic plaque/peripheral membrane proteins.

Cell adhesion molecules form a diverse group of cell surface proteins that are specialized in mediating adhesion at the cell–cell and cell–substrate interface and play important roles in a variety of physiological processes, ranging from organogenesis to adhesion in …

Cell adhesion molecules (CAMs) are now known to mediate much more than adhesion between cells and between cells and the extracellular matrix. Work by many researchers has illuminated their roles in modulating activation of molecules such as receptor tyrosine kinases, with subsequent effects on cell survival, migration and process extension.

Highlights • Cell adhesion to the extracellular matrix (ECM) is vital for multicellular life. • Complexes of structural and signalling proteins link the ECM to the cytoskeleton. • Adhesion signalling networks are complex, diverse, dynamic and tightly regulated. • Some adhesion proteins perform unexpected functions away from cell-matrix ...