2019年1月4日 · Adipose tissue can increase in size in one of two main ways: hypertrophy (increase in size of existing adipocytes) or hyperplasia (formation of new adipocytes through differentiation of...

2023年12月26日 · Our study describes an important role of SMYD3 as a newly discovered regulator of adipocyte precursor proliferation during the early steps of adipogenesis. The etiology of obesity is...

2023年6月19日 · Adipogenesis of adipose progenitor cells is considered metabolically beneficial. Two laboratories have simultaneously discovered that adipose progenitors also give rise to structural...

Growth factors such as insulin-like growth factor 1 (IGF-1) and fibroblast growth factor type 1 (FGF1) are crucial regulators of cell proliferation, survival, and differentiation and participate in the regulation of hyperplasia in adipose tissue [109,110,111].

Adipose tissue grows by two mechanisms: hyperplasia (cell number increase) and hypertrophy (cell size increase). Genetics and diet affect the relative contributions of these two mechanisms to the growth of adipose tissue in obesity. In this study, ...

2023年8月4日 · At the molecular level, adipose tissue hypoplasia can arise from differentiation, proliferation, and survival dysregulation through several key molecular regulators such as peroxisome-proliferator-activated receptor-gamma (PPARγ), CCAAT-Enhancer-Binding Proteins (C/EBPs), insulin-like growth factor 1 (IGF-1), and a fibroblast-growth-factor ...

2014年1月7日 · Adipose tissue (AT) of obese mice and humans accumulates immune cells, which secrete cytokines that can promote insulin resistance. AT macrophages (ATMs) are thought to originate from bone-marrow-derived monocytes, which infiltrate the tissue from the circulation.

Adipose tissue plays a significant role in whole body energy homeostasis. Obesity-associated diabetes, fatty liver and metabolic syndrome are closely linked to adipose stress and dysfunction. Genetic predisposition, overeating and physical inactivity …

2020年4月4日 · Adipose Tissue in the Regulation of Lipid Metabolism. Adipose tissue stores body fat as neutral TAGs and represents the chief energy reservoir within mammals. Although many diverse cell types are found in whole AT, adipocytes constitute the largest cell volumes and are the defining AT cell type.

2022年2月3日 · Adipose tissue plays a central role in maintaining whole-body insulin sensitivity and energy levels. Adipose tissue regulates insulin action via the secretion of insulin-sensitizing factors like adiponectin and by sequestering lipids, which would otherwise accumulate in other tissues and have deleterious effects.