2024年12月24日 · ADORA1 (Adenosine A1 Receptor) is a Protein Coding gene. Diseases associated with ADORA1 include Parkinson Disease 13, Autosomal Dominant and Parkinson's Disease. Among its related pathways are Purinergic signaling and GPCR downstream signalling.

The adenosine A1 receptor (A1AR) [5] is one member of the adenosine receptor group of G protein-coupled receptors with adenosine as endogenous ligand. A 1 receptors are implicated in sleep promotion by inhibiting wake-promoting cholinergic neurons in the basal forebrain. [6] .

2025年2月8日 · Title: The ADORA1 mutation linked to early-onset Parkinson's disease alters adenosine A(1)-A(2A) receptor heteromer formation and function. Crystal structure of the alpha1B-adrenergic receptor reveals molecular determinants of selective ligand recognition.

2020年3月16日 · Here, we show that tumor ADORA1 deletion suppresses cell growth in human melanoma cell lines in vitro and tumor development in vivo in immune-deficient xenografts. However, this deletion induces the upregulation of PD-L1 levels, which inactivates cocultured T cells in vitro, compromises anti-tumor i …

Adenosine A1 Receptor (ADORA1) is an adenosine receptor particularly relevant to the immunomodulatory process of malignant tumors, with four family members (ADORA1, ADORA2a, ADORA2b and ADORA3) playing regulatory roles in vitro 10-12. Adenosine has been reported to accumulate abnormally in the tumor microenvironment and binds to adenosine ...

2020年10月16日 · We found that cADORA 1 signaling reduces body weight while also inducing adipose tissue lipolysis. cADORA 1 signaling also increases adipose tissue sympathetic norepinephrine content. In contrast,...

2025年2月8日 · The ADORA1 mutation linked to early-onset Parkinson's disease alters adenosine A1-A2A receptor heteromer formation and function. Crystal structure of the alpha1B-adrenergic receptor reveals molecular determinants of selective ligand recognition.

There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process.

与人类 adora1（腺苷 a1 受体）同源。 [由基因组资源联盟提供，2022 年 4 月] Predicted to enable several functions, including G protein-coupled Adenosine Receptor activity; G-protein beta/gamma-subunit complex binding activity; and heterotrimeric G-protein binding activity.

结论： ADORA1是肝细胞癌中重要的癌蛋白，并通过PI3K/AKT信号通路促进细胞增殖。 Objective: Hepatocellular carcinoma (HCC) is a common malignancy worldwide. Although the contradictory role of ADORA1 has been explored in certain types of cancers, its clinical significance and function in hepatocellular carcinoma cells are largely unknown.